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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Trends+Cell+Biol
2015 ; 25
(6
): 354-63
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How to control self-digestion: transcriptional, post-transcriptional, and
post-translational regulation of autophagy
#MMPMID25759175
Feng Y
; Yao Z
; Klionsky DJ
Trends Cell Biol
2015[Jun]; 25
(6
): 354-63
PMID25759175
show ga
Macroautophagy (hereafter autophagy), literally defined as a type of self-eating,
is a dynamic cellular process in which cytoplasm is sequestered within a unique
compartment termed the phagophore. Upon completion, the phagophore matures into a
double-membrane autophagosome that fuses with the lysosome or vacuole, allowing
degradation of the cargo. Nonselective autophagy is primarily a cytoprotective
response to various types of stress; however, the process can also be highly
selective. Autophagy is involved in various aspects of cell physiology, and its
dysregulation is associated with a range of diseases. The regulation of autophagy
is complex, and the process must be properly modulated to maintain cellular
homeostasis. In this review, we focus on the current state of knowledge
concerning transcriptional, post-transcriptional, and post-translational
regulation of autophagy in yeast and mammals.