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10.1016/j.cell.2015.04.026 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.04.026 C4441829!4441829!25981666     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 161 (5): 1152-63 Nephropedia Template TP {{tp|p=25981666|t=2015. Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids |pdf=|usr=}}{{25981666}} gab.com Text Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25981666 #FOAvip Cells adapt to temperature shifts by adjusting levels of lipid desaturation and membrane fluidity. This fundamental process occurs in nearly all forms of life, but its mechanism in eukaryotes is unknown. We discovered that the evolutionarily conserved C. elegans gene acdh-11 (acyl-CoA-dehydrogenase, ACDH) facilitates heat adaptation by regulating the lipid desaturase FAT-7. Human ACDH deficiency causes the most common inherited disorders of fatty acid oxidation, with syndromes that are exacerbated by hyperthermia. Heat up-regulates acdh-11 expression to decrease fat-7 expression. We solved the high-resolution crystal structure of ACDH-11 and established the molecular basis of its selective and high-affinity binding to C11/C12-chain fatty acids. ACDH-11 sequesters C11/C12-chain fatty acids and prevents these fatty acids from activating nuclear hormone receptors and driving fat-7 expression. Thus, the ACDH-11 pathway drives heat adaptation by linking temperature shifts to regulation of lipid desaturase levels and membrane fluidity via an unprecedented mode of fatty acid signaling. Twit Text FOAVip Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25981666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25981666 #FOAvip English Wikipedia <ref>{{Cite pmid|25981666}}</ref> Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids #MMPMID25981666 Ma DK; Li Z; Lu AY; Sun F; Chen S; Rothe M; Menzel R; Sun F; Horvitz HR Cell 2015[May]; 161 (5): 1152-63 PMID25981666show ga Cells adapt to temperature shifts by adjusting levels of lipid desaturation and membrane fluidity. This fundamental process occurs in nearly all forms of life, but its mechanism in eukaryotes is unknown. We discovered that the evolutionarily conserved C. elegans gene acdh-11 (acyl-CoA-dehydrogenase, ACDH) facilitates heat adaptation by regulating the lipid desaturase FAT-7. Human ACDH deficiency causes the most common inherited disorders of fatty acid oxidation, with syndromes that are exacerbated by hyperthermia. Heat up-regulates acdh-11 expression to decrease fat-7 expression. We solved the high-resolution crystal structure of ACDH-11 and established the molecular basis of its selective and high-affinity binding to C11/C12-chain fatty acids. ACDH-11 sequesters C11/C12-chain fatty acids and prevents these fatty acids from activating nuclear hormone receptors and driving fat-7 expression. Thus, the ACDH-11 pathway drives heat adaptation by linking temperature shifts to regulation of lipid desaturase levels and membrane fluidity via an unprecedented mode of fatty acid signaling. äAcyl-CoA dehydrogenase drives heat adaptation by sequestering fatty ac(epmc).pdf DeepDyve Pubget Overpricing