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10.1002/hep.27671 http://scihub22266oqcxt.onion/10.1002/hep.27671 C4441614!4441614 !25546547     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25546547 &cmd=llinks): Failed to open stream: HTTP request failed! 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Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways |pdf=|usr=}}{{25546547 }} gab.com Text Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=25546547 #FOAvip Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs (miRNAs) could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and efficient and sustained inhibition of miR-21 by using highly hepatic tropic adeno-associated virus serotype 8 (rAAV8), which protected mice against lethal schistosome infection through attenuation of hepatic fibrosis (HF). We demonstrated an additive role of interleukin (IL)-13 and transforming growth factor beta 1 (TGF-?1) in up-regulating miR-21 expression in hepatic stellate cells (HSCs) by activation of mothers against decapentaplegic (SMAD) proteins. Furthermore, down-regulation of miR-21 in HSCs reversed HF by enhancing SMAD7 expression, thus repressing TGF-?1/Smad and IL-13/Smad pathways. CONCLUSION: This study suggests the mechanism of IL-13-mediated schistosomiasis HF by up-regulation of miR-21 and highlights the potential of rAAV8-mediated miR-21 inhibition as a therapeutic intervention for hepatic fibrotic diseases, such as schistosomiasis. Twit Text FOAVip Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=25546547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25546547 #FOAvip English Wikipedia <ref>{{Cite pmid|25546547 }}</ref> Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways #MMPMID25546547 He X ; Xie J ; Zhang D ; Su Q ; Sai X ; Bai R ; Chen C ; Luo X ; Gao G ; Pan W Hepatology 2015[Jun]; 61 (6 ): 2008-2017 PMID25546547 show ga Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs (miRNAs) could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and efficient and sustained inhibition of miR-21 by using highly hepatic tropic adeno-associated virus serotype 8 (rAAV8), which protected mice against lethal schistosome infection through attenuation of hepatic fibrosis (HF). We demonstrated an additive role of interleukin (IL)-13 and transforming growth factor beta 1 (TGF-?1) in up-regulating miR-21 expression in hepatic stellate cells (HSCs) by activation of mothers against decapentaplegic (SMAD) proteins. Furthermore, down-regulation of miR-21 in HSCs reversed HF by enhancing SMAD7 expression, thus repressing TGF-?1/Smad and IL-13/Smad pathways. CONCLUSION: This study suggests the mechanism of IL-13-mediated schistosomiasis HF by up-regulation of miR-21 and highlights the potential of rAAV8-mediated miR-21 inhibition as a therapeutic intervention for hepatic fibrotic diseases, such as schistosomiasis. |Adenoviridae [MESH] |Animals [MESH] |Down-Regulation [MESH] |Hepatic Stellate Cells/metabolism [MESH] |Interleukin-13/*metabolism [MESH] |Liver Diseases, Parasitic/*etiology/metabolism [MESH] |Male [MESH] |Mice, Inbred BALB C [MESH] |MicroRNAs/*metabolism [MESH] |Schistosomiasis/*etiology/metabolism [MESH] |Smad7 Protein/metabolism [MESH]Recombinant adeno-associated virus-mediated inhibition of microRNA-21 (epmc).pdf DeepDyve Pubget Overpricing