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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arterioscler+Thromb+Vasc+Biol
2015 ; 35
(6
): 1298-305
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English Wikipedia
2013 scientific sessions Sol Sherry distinguished lecture in thrombosis:
polyphosphate: a novel modulator of hemostasis and thrombosis
#MMPMID25908762
Smith SA
; Morrissey JH
Arterioscler Thromb Vasc Biol
2015[Jun]; 35
(6
): 1298-305
PMID25908762
show ga
Polyphosphate is a highly anionic, linear polymer of inorganic phosphates that is
found throughout biology, including in many infectious microorganisms. Recently,
polyphosphate was discovered to be stored in a subset of the secretory granules
of human platelets and mast cells, and to be secreted on activation of these
cells. Work from our laboratory and others has now shown that polyphosphate is a
novel, potent modulator of the blood clotting and complement systems that likely
plays roles in hemostasis, thrombosis, inflammation, and host responses to
pathogens. Therapeutics targeting polyphosphate may have the potential to limit
thrombosis with fewer hemorrhagic complications than conventional anticoagulant
drugs that target essential proteases of the blood clotting cascade.
|Blood Coagulation/physiology
[MESH]
|Factor V/physiology
[MESH]
|Factor XI/physiology
[MESH]
|Fibrin/chemistry/drug effects
[MESH]
|Fibrinolysis/drug effects
[MESH]
|Hemostasis/*physiology
[MESH]
|Humans
[MESH]
|Molecular Structure
[MESH]
|Polyphosphates/*metabolism/pharmacology/*therapeutic use
[MESH]