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10.1101/gad.259432.115 http://scihub22266oqcxt.onion/10.1101/gad.259432.115 C4441053!4441053 !25943375     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25943375 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (10 ): 1058-73 Nephropedia Template TP {{tp|p=25943375 |t=2015. Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N |pdf=|usr=}}{{25943375 }} gab.com Text Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25943375 #FOAvip Specific recognition of centromere-specific histone variant CENP-A-containing chromatin by CENP-N is an essential process in the assembly of the kinetochore complex at centromeres prior to mammalian cell division. However, the mechanisms of CENP-N recruitment to centromeres/kinetochores remain unknown. Here, we show that a CENP-A-specific RG loop (Arg80/Gly81) plays an essential and dual regulatory role in this process. The RG loop assists the formation of a compact "ladder-like" structure of CENP-A chromatin, concealing the loop and thus impairing its role in recruiting CENP-N. Upon G1/S-phase transition, however, centromeric chromatin switches from the compact to an open state, enabling the now exposed RG loop to recruit CENP-N prior to cell division. Our results provide the first insights into the mechanisms by which the recruitment of CENP-N is regulated by the structural transitions between compaction and relaxation of centromeric chromatin during the cell cycle. Twit Text FOAVip Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25943375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25943375 #FOAvip English Wikipedia <ref>{{Cite pmid|25943375 }}</ref> Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N #MMPMID25943375 Fang J ; Liu Y ; Wei Y ; Deng W ; Yu Z ; Huang L ; Teng Y ; Yao T ; You Q ; Ruan H ; Chen P ; Xu RM ; Li G Genes Dev 2015[May]; 29 (10 ): 1058-73 PMID25943375 show ga Specific recognition of centromere-specific histone variant CENP-A-containing chromatin by CENP-N is an essential process in the assembly of the kinetochore complex at centromeres prior to mammalian cell division. However, the mechanisms of CENP-N recruitment to centromeres/kinetochores remain unknown. Here, we show that a CENP-A-specific RG loop (Arg80/Gly81) plays an essential and dual regulatory role in this process. The RG loop assists the formation of a compact "ladder-like" structure of CENP-A chromatin, concealing the loop and thus impairing its role in recruiting CENP-N. Upon G1/S-phase transition, however, centromeric chromatin switches from the compact to an open state, enabling the now exposed RG loop to recruit CENP-N prior to cell division. Our results provide the first insights into the mechanisms by which the recruitment of CENP-N is regulated by the structural transitions between compaction and relaxation of centromeric chromatin during the cell cycle. |Cell Cycle/*physiology [MESH] |Cell Line [MESH] |Cell Proliferation [MESH] |Centromere/*chemistry/*metabolism [MESH] |Chromatin/*chemistry/metabolism [MESH] |Chromosomal Proteins, Non-Histone/chemistry/*metabolism [MESH] |Chromosomes/metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Kinetochores/chemistry/metabolism [MESH] |Protein Binding [MESH] |Protein Transport [MESH]Structural transitions of centromeric chromatin regulate the cell cycl(epmc).pdf DeepDyve Pubget Overpricing