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10.1101/gad.259432.115

http://scihub22266oqcxt.onion/10.1101/gad.259432.115
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C4441053!4441053!25943375
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suck abstract from ncbi


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pmid25943375      Genes+Dev 2015 ; 29 (10): 1058-73
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  • Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N #MMPMID25943375
  • Fang J; Liu Y; Wei Y; Deng W; Yu Z; Huang L; Teng Y; Yao T; You Q; Ruan H; Chen P; Xu RM; Li G
  • Genes Dev 2015[May]; 29 (10): 1058-73 PMID25943375show ga
  • Specific recognition of centromere-specific histone variant CENP-A-containing chromatin by CENP-N is an essential process in the assembly of the kinetochore complex at centromeres prior to mammalian cell division. Fang et al. show that a CENP-A-specific RG loop (Arg80/Gly81) plays an essential and dual regulatory role in this process, providing insights into the mechanisms by which the recruitment of CENP-N is regulated by the structural transitions between compaction and relaxation of centromeric chromatin during the cell cycle.
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