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10.1088/0031-9155/60/7/2853 http://scihub22266oqcxt.onion/10.1088/0031-9155/60/7/2853 C4440415!4440415 !25776065     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25776065 &cmd=llinks): Failed to open stream: HTTP request failed! 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Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using harmonic motion imaging (HMI) |pdf=|usr=}}{{25776065 }} gab.com Text Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using harmonic motion imaging (HMI) JO: Phys Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=25776065 #FOAvip Noninvasive measurement of mechanical properties of biological tissues in vivo could play a significant role in improving the current understanding of tissue biomechanics. In this study, we propose a method for measuring elastic properties non-invasively by using internal indentation as generated by harmonic motion imaging (HMI). In HMI, an oscillating acoustic radiation force is produced by a focused ultrasound transducer at the focal region, and the resulting displacements are estimated by tracking radiofrequency signals acquired by an imaging transducer. In this study, the focal spot region was modeled as a rigid cylindrical piston that exerts an oscillatory, uniform internal force to the underlying tissue. The HMI elastic modulus EHMI was defined as the ratio of the applied force to the axial strain measured by 1D ultrasound imaging. The accuracy and the precision of the EHMI estimate were assessed both numerically and experimentally in polyacrylamide tissue-mimicking phantoms. Initial feasibility of this method in soft tissues was also shown in canine liver specimens in vitro. Very good correlation and agreement was found between the measured Young's modulus and the HMI modulus in the numerical study (r(2) > 0.99, relative error <10%) and on polyacrylamide gels (r(2) = 0.95, relative error <24%). The average HMI modulus on five liver samples was found to EHMI = 2.62? ± ?0.41?kPa, compared to EMechTesting = 4.2? ± ?2.58?kPa measured by rheometry. This study has demonstrated for the first time the initial feasibility of a non-invasive, model-independent method to estimate local elastic properties of biological tissues at a submillimeter scale using an internal indentation-like approach. Ongoing studies include in vitro experiments in a larger number of samples and feasibility testing in in vivo models as well as pathological human specimens. Twit Text FOAVip Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using harmonic motion imaging (HMI) ????Phys Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=25776065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25776065 #FOAvip English Wikipedia <ref>{{Cite pmid|25776065 }}</ref> Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using harmonic motion imaging (HMI) #MMPMID25776065 Vappou J ; Hou GY ; Marquet F ; Shahmirzadi D ; Grondin J ; Konofagou EE Phys Med Biol 2015[Apr]; 60 (7 ): 2853-68 PMID25776065 show ga Noninvasive measurement of mechanical properties of biological tissues in vivo could play a significant role in improving the current understanding of tissue biomechanics. In this study, we propose a method for measuring elastic properties non-invasively by using internal indentation as generated by harmonic motion imaging (HMI). In HMI, an oscillating acoustic radiation force is produced by a focused ultrasound transducer at the focal region, and the resulting displacements are estimated by tracking radiofrequency signals acquired by an imaging transducer. In this study, the focal spot region was modeled as a rigid cylindrical piston that exerts an oscillatory, uniform internal force to the underlying tissue. The HMI elastic modulus EHMI was defined as the ratio of the applied force to the axial strain measured by 1D ultrasound imaging. The accuracy and the precision of the EHMI estimate were assessed both numerically and experimentally in polyacrylamide tissue-mimicking phantoms. Initial feasibility of this method in soft tissues was also shown in canine liver specimens in vitro. Very good correlation and agreement was found between the measured Young's modulus and the HMI modulus in the numerical study (r(2) > 0.99, relative error <10%) and on polyacrylamide gels (r(2) = 0.95, relative error <24%). The average HMI modulus on five liver samples was found to EHMI = 2.62? ± ?0.41?kPa, compared to EMechTesting = 4.2? ± ?2.58?kPa measured by rheometry. This study has demonstrated for the first time the initial feasibility of a non-invasive, model-independent method to estimate local elastic properties of biological tissues at a submillimeter scale using an internal indentation-like approach. Ongoing studies include in vitro experiments in a larger number of samples and feasibility testing in in vivo models as well as pathological human specimens. |Acrylic Resins/chemistry [MESH] |Animals [MESH] |Biomechanical Phenomena [MESH] |Diagnostic Imaging/*methods [MESH] |Dogs [MESH] |Elastic Modulus [MESH] |Elasticity Imaging Techniques/*methods [MESH] |High-Energy Shock Waves [MESH] |Humans [MESH] |Liver/*diagnostic imaging/pathology [MESH] |Models, Theoretical [MESH] |Motion [MESH] |Oscillometry [MESH] |Phantoms, Imaging [MESH] |Reproducibility of Results [MESH]Non-contact, ultrasound-based indentation method for measuring elastic(epmc).pdf DeepDyve Pubget Overpricing