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2015 ; 8
(3
): 3304-7
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Erythema, papules, and arthralgia associated with liver cancer: report of a rare
case of multicentric reticulohistiocytosis
#MMPMID26045857
Hu L
; Mei JH
; Xia J
; Hao QS
; Cheng LP
; Wu YH
Int J Clin Exp Pathol
2015[]; 8
(3
): 3304-7
PMID26045857
show ga
We report a rare case of multicentric reticulohistiocytosis (MRH) associated with
liver carcinoma. A 36-year-old man who had been diagnosed as having liver
carcinoma for 2 years presented with a 2-month history of multiple papulonodules
on the face, ears, neck, and upper chest, accompanied by progressive
polyarthralgia of the hands, wrists, elbows and knee joints without fever or
chills. Skin histology revealed well defined dermal infiltrate consisting of
multinucleated giant cells and macrophages having abundant eosinophilic finely
granular cytoplasm with ground glass appearance. Further immunohistochemical
studies characterized the lesions as positive for CD68, CD45 and Vimentin. A
diagnosis of MRH that was associated with liver cancer was made. Treatment with
prednisolone for 2 months resulted in a significant improvement of the skin and
joint symptoms, but was discontinued due to his significant enlargement and
extensive metastases of the liver carcinoma.