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2015 ; 8
(3
): 3204-9
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gab.com Text
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Incidence of anticardiolipin antibodies and lupus anticoagulant factor among
women experiencing unexplained recurrent abortion and intrauterine fetal death
#MMPMID26045841
Al Jameil N
; Tyagi P
; Al Shenefy A
Int J Clin Exp Pathol
2015[]; 8
(3
): 3204-9
PMID26045841
show ga
The aim of this research study was to estimate anticardiolipin (IgG & IgM)
antibodies (aCL) and lupus anticoagulant (LA) factor in patients of recurrent
unexplained pregnancy loss and intrauterine fetal deaths (IUFD). 82 women were
selected for this study by virtue of having more than two consecutive unexplained
pregnancy losses in their first trimester and were referred by the department of
Obstetrics and Gynecology, King Saud Medical City Hospital, Riyadh, KSA. All
patients had gone through a standardized investigation sequence. Lupus
anticoagulants and Anticardiolipin antibodies (IgM and IgG) were detected in the
serum by the enzyme linked immunosorbent assay method. To check the significance
of aCL and LA, two-tailed t-test was done. Non parametric data was calculated
either by Chi-Square test or Fischer exact test when relevant. Total 82 females
grouped as 52 cases of recurrent (?2) mainly first and second trimester
miscarriage and 30 cases of recurrent (?2) late intrauterine fetal death. Lupus
anticoagulants was observed in twenty one (21) cases (25.6%) while
anticardiolipin antibodies IgM and or IgG positive cases were estimated in forty
four (44) cases (53.65%). The prevalence of APS in both studied group was thirty
five (35) cases (42.68%). Antiphospholipid antibodies are calculated as the most
important reason for recurrent abortion. The patients with unexplained recurrent
pregnancy loss must be advised to go for a screening test for all this aPL
antibodies.