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Expression of vascular endothelial growth factor and basic fibroblast growth
factor in extramammary Paget disease
#MMPMID26045818
Xu X
; Shao N
; Qiao D
; Wang Z
; Song N
; Song N
Int J Clin Exp Pathol
2015[]; 8
(3
): 3062-8
PMID26045818
show ga
Extramammary Paget's disease (EMPD) is a special type of cancers. The etiology of
the disease is still unclear. We aimed to study the expression differences of
vascular endothelial growth factor (VEGF) and basic fibroblast growth factor
(bFGF) in EMPD tissues and corresponding adjacent normal tissues. The mRNA
expression was detected by RT-PCR and the protein expression was explored by
immunohistochemistry. Higher immunostaining signal scores of bFGF and VEGF in
EMPD tissues had been found (z=-3.827, P<0.001, z=-3.729, P<0.001, respectively).
In addition, the mRNA expression of bFGF and VEGF was higher in EMPD tissues,
which had been validated by RT-PCR (t=5.771, P<0.001, t=3.304, P=0.004,
respectively). The VEGF and bFGF might be the key signaling proteins in
angiogenesis of EMPD. How to block the VEGF and bFGF in EMPD and to destroy the
blood supply of the tumor cells becomes the focus of our future research.
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