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Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma |pdf=|usr=}}{{26045809 }} gab.com Text Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26045809 #FOAvip INTRODUCTION: Long non-coding RNAs (lncRNAs) are aberrantly expressed in many diseases including cancer. LncRNA HULC (highly up-regulated in liver cancer) has recently been revealed to be involved in hepatocellular carcinoma development and progression. However, the role and function of HULC in human osteosarcoma remains unknown. METHODS: LncRNA HULC expression in osteosarcoma tissues and cell lines was detected by quantitative real-time PCR. Then, the association of HULC level with survival of osteosarcoma patients was performed by the Kaplan-Meier and Cox proportional regression analyses. Furthermore, the effects of HULC on tumorigenicity of osteosarcoma cells were evaluated by in vitro assays. RESULTS: In the present study, we demonstrated that HULC was significantly up-regulated in osteosarcoma tissues and cell lines compared with normal controls, and over-expression of HULC was correlated with clinical stage and distant metastasis. Moreover, higher HULC expression was associated with shorter overall survival of osteosarcoma patients. Furthermore, decreased expression of HULC markedly suppressed osteosarcoma cell proliferation, migration, and invasion. CONCLUSIONS: Our results indicated that HULC is a novel molecule involved in osteosarcoma progression, which may provide a new marker of poor prognosis and a potential therapeutic target for osteosarcoma intervention. Twit Text FOAVip Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26045809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26045809 #FOAvip English Wikipedia <ref>{{Cite pmid|26045809 }}</ref> Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma #MMPMID26045809 Sun XH ; Yang LB ; Geng XL ; Wang R ; Zhang ZC Int J Clin Exp Pathol 2015[]; 8 (3 ): 2994-3000 PMID26045809 show ga INTRODUCTION: Long non-coding RNAs (lncRNAs) are aberrantly expressed in many diseases including cancer. LncRNA HULC (highly up-regulated in liver cancer) has recently been revealed to be involved in hepatocellular carcinoma development and progression. However, the role and function of HULC in human osteosarcoma remains unknown. METHODS: LncRNA HULC expression in osteosarcoma tissues and cell lines was detected by quantitative real-time PCR. Then, the association of HULC level with survival of osteosarcoma patients was performed by the Kaplan-Meier and Cox proportional regression analyses. Furthermore, the effects of HULC on tumorigenicity of osteosarcoma cells were evaluated by in vitro assays. RESULTS: In the present study, we demonstrated that HULC was significantly up-regulated in osteosarcoma tissues and cell lines compared with normal controls, and over-expression of HULC was correlated with clinical stage and distant metastasis. Moreover, higher HULC expression was associated with shorter overall survival of osteosarcoma patients. Furthermore, decreased expression of HULC markedly suppressed osteosarcoma cell proliferation, migration, and invasion. CONCLUSIONS: Our results indicated that HULC is a novel molecule involved in osteosarcoma progression, which may provide a new marker of poor prognosis and a potential therapeutic target for osteosarcoma intervention. |Adolescent [MESH] |Adult [MESH] |Bone Neoplasms/*genetics/mortality/pathology [MESH] |Child [MESH] |Female [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Male [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Osteosarcoma/*genetics/mortality/pathology [MESH] |Prognosis [MESH] |Proportional Hazards Models [MESH] |RNA, Long Noncoding/biosynthesis/*genetics [MESH] |RNA, Small Interfering [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Transfection [MESH]Increased expression of lncRNA HULC indicates a poor prognosis and pro(epmc).pdf DeepDyve Pubget Overpricing