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2015 ; 8
(3
): 2909-18
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Association between KIAA1199 overexpression and tumor invasion, TNM stage, and
poor prognosis in colorectal cancer
#MMPMID26045799
Xu J
; Liu Y
; Wang X
; Huang J
; Zhu H
; Hu Z
; Wang D
Int J Clin Exp Pathol
2015[]; 8
(3
): 2909-18
PMID26045799
show ga
To investigate the expression of KIAA1199 in tumor tissue and its potential value
as a prognostic indicator of survival in patients with colorectal cancer (CRC).
The expression of KIAA1199 mRNA in CRC was characterized using real-time PCR and
20 pairs of fresh-frozen CRC tissues and corresponding non-cancerous tissues.
KIAA1199 protein expression was confirmed using immunohistochemistry on a tissue
microarray chip from 202 patients with CRC. Then, we correlated KIAA1199 protein
expression to CRC conventional clinicopathological features and patient's
outcome. The expression of KIAA1199 mRNA and protein were up-regulated in CRC
compared to normal tissues (P=0.015 and P<0.001, individually). KIAA1199 protein
expression was related to tumor invasion depth (P=0.013) and lymph node
metastasis (P=0.003). Kaplan-Meier survival and Cox regression analyses revealed
that high KIAA1199 expression (P<0.001) and serum carcinoembryonic antigen (CEA)
level post operation (P=0.005) were independent factors predicting poor prognosis
of patients with CRC. We present evidence that high expression of KIAA1199 is
associated with tumor invasion depth, TNM stage, and poor prognosis in CRC. Our
findings suggest KIAA1199 could be used as a prognostic factor and novel
therapeutic target for CRC.