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pmid26045791      Int+J+Clin+Exp+Pathol 2015 ; 8 (3): 2829-34
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  • MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9 #MMPMID26045791
  • Tong XD; Liu TQ; Wang GB; Zhang CL; Liu HX
  • Int J Clin Exp Pathol 2015[]; 8 (3): 2829-34 PMID26045791show ga
  • Increasing studies have shown that MicroRNAs (miRNAs) play critical roles in the progression of lung carcinoma. In the present study, the expression and functions of miR-570 were investigated. We found that miR-570 was significantly up-regulated in lung cancer tissues, compared with adjacent non-cancerous tissues. In vitro studies further showed that miR-570 mimics could promote, while its antisense oligos inhibit cell proliferation and invasion. At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells. Indeed, miR-570 could negatively regulate protein levels of KLF9 through targeting its 3?-untranslated region. Taken together, our results suggest a previously unknown miR-570/KLF9 molecular network controlling lung carcinoma progression.
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