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suck abstract from ncbi


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pmid26045766
      Int+J+Clin+Exp+Pathol 2015 ; 8 (3 ): 2603-14
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  • Immunity of fungal infections alleviated graft reject in liver transplantation compared with non-fungus recipients #MMPMID26045766
  • Xing T ; Zhong L ; Lin L ; Qiu G ; Peng Z
  • Int J Clin Exp Pathol 2015[]; 8 (3 ): 2603-14 PMID26045766 show ga
  • OBJECTIVE: To evaluate of the immune tolerance in adult LT recipients with Invasive fungal infections (IFIs). METHODS: 109 consecutive LT recipients who received LT were included. Percentage of T subsets (CD4+CD25hiCD127- T cells, CD4+CD25loCD45RA+ T cells, CD4+CD25loCD45RA- and CD4+CD45RA-CD45RO+ T cells populations), levels of cytokines (IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-?, IL-12p70, IL-17, TNF-?, TNF-? and GM-CSF) were detected by FACS and Bioplex in peripheral blood. Biopsy specimens were fixed, monoclonal antibodies against CD4, Foxp3 and IL-17 were applied to the above sections and FISH was performed. RESULTS: The risk of acute rejection was decreased in fungal infected liver transplant recipients comparing with non-fungal infected group. CD4+CD25hiCD127T cell population was increased in peripheral blood and memory CD4+CD45RA-CD45RO+ T cell population decreased. There was significant lower levels observed in naïve CD4+CD25loCD45RA+ and CD4+CD25loCD45RA- T cell populations in fungal infected liver transplant. Moreover, IL-2, IL-6, IL-10 and GM-CSF were decreased. However, no significant difference with IL-4 and IL-8 in serum in two infected LT recipients. CONCLUSION: The incidence of graft rejection in liver transplantation recipients with fungal infections was lower than the non-fungal group. It is important to assess the risk during pretransplant and postoperation for liver transplantation.
  • |Adult [MESH]
  • |Cytokines/blood/immunology [MESH]
  • |Female [MESH]
  • |Flow Cytometry [MESH]
  • |Graft Rejection/*epidemiology/*immunology [MESH]
  • |Humans [MESH]
  • |Immunocompromised Host/*immunology [MESH]
  • |Immunohistochemistry [MESH]
  • |In Situ Hybridization, Fluorescence [MESH]
  • |Liver Transplantation/*adverse effects [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Mycoses/epidemiology/*immunology [MESH]
  • |Retrospective Studies [MESH]


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