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2015 ; 8
(3
): 2603-14
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Immunity of fungal infections alleviated graft reject in liver transplantation
compared with non-fungus recipients
#MMPMID26045766
Xing T
; Zhong L
; Lin L
; Qiu G
; Peng Z
Int J Clin Exp Pathol
2015[]; 8
(3
): 2603-14
PMID26045766
show ga
OBJECTIVE: To evaluate of the immune tolerance in adult LT recipients with
Invasive fungal infections (IFIs). METHODS: 109 consecutive LT recipients who
received LT were included. Percentage of T subsets (CD4+CD25hiCD127- T cells,
CD4+CD25loCD45RA+ T cells, CD4+CD25loCD45RA- and CD4+CD45RA-CD45RO+ T cells
populations), levels of cytokines (IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-?,
IL-12p70, IL-17, TNF-?, TNF-? and GM-CSF) were detected by FACS and Bioplex in
peripheral blood. Biopsy specimens were fixed, monoclonal antibodies against CD4,
Foxp3 and IL-17 were applied to the above sections and FISH was performed.
RESULTS: The risk of acute rejection was decreased in fungal infected liver
transplant recipients comparing with non-fungal infected group. CD4+CD25hiCD127T
cell population was increased in peripheral blood and memory CD4+CD45RA-CD45RO+ T
cell population decreased. There was significant lower levels observed in naïve
CD4+CD25loCD45RA+ and CD4+CD25loCD45RA- T cell populations in fungal infected
liver transplant. Moreover, IL-2, IL-6, IL-10 and GM-CSF were decreased. However,
no significant difference with IL-4 and IL-8 in serum in two infected LT
recipients. CONCLUSION: The incidence of graft rejection in liver transplantation
recipients with fungal infections was lower than the non-fungal group. It is
important to assess the risk during pretransplant and postoperation for liver
transplantation.