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10.1002/eji.201444778 http://scihub22266oqcxt.onion/10.1002/eji.201444778 C4440042!4440042 !25630305     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25630305 &cmd=llinks): Failed to open stream: HTTP request failed! 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Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma |pdf=|usr=}}{{25630305 }} gab.com Text Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25630305 #FOAvip Studies examining the role of PD-1 family members in allergic asthma have yielded conflicting results. Using a mouse model of allergic asthma, we demonstrate that blockade of PD-1/PD-L1 has distinct influences on different CD4(+) T-cell subsets. PD-1/PD-L1 blockade enhances airway hyperreactivity (AHR), not by altering the magnitude of the underlying Th2-type immune response, but by allowing the development of a concomitant Th17-type immune response. Supporting differential CD4(+) T-cell responsiveness to PD-1-mediated inhibition, naïve PD-1(-/-) mice displayed elevated Th1 and Th17 levels, but diminished Th2 cytokine levels, and ligation of PD-1 in WT cells limited cytokine production by in vitro polarized Th1 and Th17 cells, but slightly enhanced cytokine production by in vitro polarized Th2 cells. Furthermore, PD-1 ligation enhanced Th2 cytokine production by naïve T cells cultured under nonpolarizing conditions. These data demonstrate that different CD4(+) T-cell subsets respond differentially to PD-1 ligation and may explain some of the variable results observed in control of allergic asthma by the PD-1 family members. As the PD-1/PD-L1 axis limits asthma severity by constraining Th17 cell activity, this suggests that severe allergic asthma may be associated with a defective PD-1/PD-L1 regulatory axis in some individuals. Twit Text FOAVip Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25630305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25630305 #FOAvip English Wikipedia <ref>{{Cite pmid|25630305 }}</ref> Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma #MMPMID25630305 McAlees JW ; Lajoie S ; Dienger K ; Sproles AA ; Richgels PK ; Yang Y ; Khodoun M ; Azuma M ; Yagita H ; Fulkerson PC ; Wills-Karp M ; Lewkowich IP Eur J Immunol 2015[Apr]; 45 (4 ): 1019-29 PMID25630305 show ga Studies examining the role of PD-1 family members in allergic asthma have yielded conflicting results. Using a mouse model of allergic asthma, we demonstrate that blockade of PD-1/PD-L1 has distinct influences on different CD4(+) T-cell subsets. PD-1/PD-L1 blockade enhances airway hyperreactivity (AHR), not by altering the magnitude of the underlying Th2-type immune response, but by allowing the development of a concomitant Th17-type immune response. Supporting differential CD4(+) T-cell responsiveness to PD-1-mediated inhibition, naïve PD-1(-/-) mice displayed elevated Th1 and Th17 levels, but diminished Th2 cytokine levels, and ligation of PD-1 in WT cells limited cytokine production by in vitro polarized Th1 and Th17 cells, but slightly enhanced cytokine production by in vitro polarized Th2 cells. Furthermore, PD-1 ligation enhanced Th2 cytokine production by naïve T cells cultured under nonpolarizing conditions. These data demonstrate that different CD4(+) T-cell subsets respond differentially to PD-1 ligation and may explain some of the variable results observed in control of allergic asthma by the PD-1 family members. As the PD-1/PD-L1 axis limits asthma severity by constraining Th17 cell activity, this suggests that severe allergic asthma may be associated with a defective PD-1/PD-L1 regulatory axis in some individuals. |Animals [MESH] |Antibodies, Monoclonal/pharmacology [MESH] |Asthma/*immunology [MESH] |B7-H1 Antigen/*immunology [MESH] |Cell Differentiation/immunology [MESH] |Cell Movement/immunology [MESH] |Cells, Cultured [MESH] |Cytokines/biosynthesis [MESH] |Disease Models, Animal [MESH] |Interleukin-12/blood [MESH] |Lung/cytology [MESH] |Mice [MESH] |Mice, Inbred C3H [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Programmed Cell Death 1 Ligand 2 Protein/antagonists & inhibitors [MESH] |Programmed Cell Death 1 Receptor/genetics/*immunology [MESH] |Pyroglyphidae/immunology [MESH] |Spleen/cytology [MESH] |T-Lymphocyte Subsets/immunology [MESH] |Th1 Cells/cytology/immunology [MESH] |Th17 Cells/cytology/*immunology [MESH]Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis i(epmc).pdf DeepDyve Pubget Overpricing