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10.1111/bph.12844 http://scihub22266oqcxt.onion/10.1111/bph.12844 C4439870!4439870!25039449     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2015 ; 172 (11): 2716-32 Nephropedia Template TP {{tp|p=25039449|t=2015. Targeting the histone orthography of cancer: drugs for writers, erasers and readers |pdf=|usr=}}{{25039449}} gab.com Text Targeting the histone orthography of cancer: drugs for writers, erasers and readers JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25039449 #FOAvip Gene expression is dynamically controlled by epigenetics through post-translational modifications of histones, chromatin-associated proteins and DNA itself. All these elements are required for the maintenance of chromatin structure and cell identity in the context of a normal cellular phenotype. Disruption of epigenetic regulation is a common event in human cancer. Here, we review the key protein families that control epigenetic signalling through writing, erasing or reading specific post-translational modifications. By exploiting the leading role of epigenetics in tumour development and the reversibility of epigenetic modifications, promising novel epigenetic-based therapies are being developed. In this article, we highlight the emerging low MW inhibitors targeting each class of chromatin-associated protein, their current use in preclinical and clinical trials and the likelihood of their being approved in the near future. Twit Text FOAVip Targeting the histone orthography of cancer: drugs for writers, erasers and readers ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25039449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25039449 #FOAvip English Wikipedia <ref>{{Cite pmid|25039449}}</ref> Targeting the histone orthography of cancer: drugs for writers, erasers and readers #MMPMID25039449 Simó-Riudalbas L; Esteller M Br J Pharmacol 2015[Jun]; 172 (11): 2716-32 PMID25039449show ga Gene expression is dynamically controlled by epigenetics through post-translational modifications of histones, chromatin-associated proteins and DNA itself. All these elements are required for the maintenance of chromatin structure and cell identity in the context of a normal cellular phenotype. Disruption of epigenetic regulation is a common event in human cancer. Here, we review the key protein families that control epigenetic signalling through writing, erasing or reading specific post-translational modifications. By exploiting the leading role of epigenetics in tumour development and the reversibility of epigenetic modifications, promising novel epigenetic-based therapies are being developed. In this article, we highlight the emerging low MW inhibitors targeting each class of chromatin-associated protein, their current use in preclinical and clinical trials and the likelihood of their being approved in the near future. äTargeting the histone orthography of cancer: drugs for writers, eraser(epmc).pdf DeepDyve Pubget Overpricing