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10.1111/bph.13096 http://scihub22266oqcxt.onion/10.1111/bph.13096 C4439867!4439867!25630872     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2015 ; 172 (11): 2675-700 Nephropedia Template TP {{tp|p=25630872|t=2015. Ten things you should know about protein kinases: IUPHAR Review 14 |pdf=|usr=}}{{25630872}} gab.com Text Ten things you should know about protein kinases: IUPHAR Review 14 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25630872 #FOAvip Many human malignancies are associated with aberrant regulation of protein or lipid kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein and lipid kinases represent an important target class for treating human disorders. This review focus on ?the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery. Although the ?10 things? have been, to a certain extent, chosen arbitrarily, they cover in a comprehensive way the past and present efforts in kinase drug discovery and summarize the status quo of the current kinase inhibitors as well as knowledge about kinase structure and binding modes. Besides describing the potentials of protein kinase inhibitors as drugs, this review also focus on their limitations, particularly on how to circumvent emerging resistance against kinase inhibitors in oncological indications. Twit Text FOAVip Ten things you should know about protein kinases: IUPHAR Review 14 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25630872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25630872 #FOAvip English Wikipedia <ref>{{Cite pmid|25630872}}</ref> Ten things you should know about protein kinases: IUPHAR Review 14 #MMPMID25630872 Fabbro D; Cowan-Jacob SW; Moebitz H Br J Pharmacol 2015[Jun]; 172 (11): 2675-700 PMID25630872show ga Many human malignancies are associated with aberrant regulation of protein or lipid kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein and lipid kinases represent an important target class for treating human disorders. This review focus on ?the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery. Although the ?10 things? have been, to a certain extent, chosen arbitrarily, they cover in a comprehensive way the past and present efforts in kinase drug discovery and summarize the status quo of the current kinase inhibitors as well as knowledge about kinase structure and binding modes. Besides describing the potentials of protein kinase inhibitors as drugs, this review also focus on their limitations, particularly on how to circumvent emerging resistance against kinase inhibitors in oncological indications. äTen things you should know about protein kinases: IUPHAR Review 14 (epmc).pdf DeepDyve Pubget Overpricing