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10.3402/pba.v5.27743 http://scihub22266oqcxt.onion/10.3402/pba.v5.27743 C4439419!4439419!25994420     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pathobiol+Aging+Age+Relat+Dis 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=25994420|t=2015. The emerging role of senescent cells in tissue homeostasis and pathophysiology |pdf=|usr=}}{{25994420}} gab.com Text The emerging role of senescent cells in tissue homeostasis and pathophysiology JO: Pathobiol Aging Age Relat Dis http://www.kidney.de/pget.php?&tw=1&pmid=25994420 #FOAvip Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal role in tumor suppression. Cellular senescence may play an important role in tumor suppression, wound healing, and protection against tissue fibrosis in physiological conditions in vivo. However, accumulating evidence that senescent cells may have harmful effects in vivo and may contribute to tissue remodeling, organismal aging, and many age-related diseases also exists. Cellular senescence can be induced by various intrinsic and extrinsic factors. Both p53/p21 and p16/RB pathways are important for irreversible growth arrest in senescent cells. Senescent cells secret numerous biologically active factors. This specific secretion phenotype by senescent cells may largely contribute to physiological and pathological consequences in organisms. Here I review the molecular basis of cell cycle arrest and the specific secretion phenotype in cellular senescence. I also summarize the current knowledge of the role of cellular senescence in vivo in physiological and pathological settings. Twit Text FOAVip The emerging role of senescent cells in tissue homeostasis and pathophysiology ????Pathobiol Aging Age Relat Dis http://www.kidney.de/pget.php?&tw=1&pmid=25994420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25994420 #FOAvip English Wikipedia <ref>{{Cite pmid|25994420}}</ref> The emerging role of senescent cells in tissue homeostasis and pathophysiology #MMPMID25994420 Tominaga K Pathobiol Aging Age Relat Dis 2015[]; 5 (ä): ä PMID25994420show ga Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal role in tumor suppression. Cellular senescence may play an important role in tumor suppression, wound healing, and protection against tissue fibrosis in physiological conditions in vivo. However, accumulating evidence that senescent cells may have harmful effects in vivo and may contribute to tissue remodeling, organismal aging, and many age-related diseases also exists. Cellular senescence can be induced by various intrinsic and extrinsic factors. Both p53/p21 and p16/RB pathways are important for irreversible growth arrest in senescent cells. Senescent cells secret numerous biologically active factors. This specific secretion phenotype by senescent cells may largely contribute to physiological and pathological consequences in organisms. Here I review the molecular basis of cell cycle arrest and the specific secretion phenotype in cellular senescence. I also summarize the current knowledge of the role of cellular senescence in vivo in physiological and pathological settings. äThe emerging role of senescent cells in tissue homeostasis and pathoph(epmc).pdf DeepDyve Pubget Overpricing