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10.1038/ni.3168 http://scihub22266oqcxt.onion/10.1038/ni.3168 C4439271!4439271!25915732     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (6): 599-608 Nephropedia Template TP {{tp|p=25915732|t=2015. Innate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor |pdf=|usr=}}{{25915732}} gab.com Text Innate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25915732 #FOAvip Diverse innate lymphoid cell (ILC) subtypes have been defined, based on effector function and transcription factor expression. ILCs derive from common lymphoid progenitors, although the transcriptional pathways leading to ILC lineage specification remain poorly characterized. Here we demonstrate that transcriptional regulator TOX is required for the in vivo differentiation of common lymphoid progenitors to ILC lineage-restricted cells. In vitro modeling demonstrates that TOX deficiency results in early defects in progenitor cell survival or expansion as well as later stage ILC differentiation. In addition, comparative transcriptome analysis of bone marrow progenitors reveals that TOX-deficient cells fail to upregulate many aspects of the ILC gene program, including Notch gene targets, implicating TOX as a key determinant of early ILC lineage specification. Twit Text FOAVip Innate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25915732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25915732 #FOAvip English Wikipedia <ref>{{Cite pmid|25915732}}</ref> Innate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor #MMPMID25915732 Seehus CR; Aliahmad P; de la Torre B; Iliev ID; Spurka L; Funari VA; Kaye J Nat Immunol 2015[Jun]; 16 (6): 599-608 PMID25915732show ga Diverse innate lymphoid cell (ILC) subtypes have been defined, based on effector function and transcription factor expression. ILCs derive from common lymphoid progenitors, although the transcriptional pathways leading to ILC lineage specification remain poorly characterized. Here we demonstrate that transcriptional regulator TOX is required for the in vivo differentiation of common lymphoid progenitors to ILC lineage-restricted cells. In vitro modeling demonstrates that TOX deficiency results in early defects in progenitor cell survival or expansion as well as later stage ILC differentiation. In addition, comparative transcriptome analysis of bone marrow progenitors reveals that TOX-deficient cells fail to upregulate many aspects of the ILC gene program, including Notch gene targets, implicating TOX as a key determinant of early ILC lineage specification. äInnate lymphoid cell development requires TOX-dependent generation of (epmc).pdf DeepDyve Pubget Overpricing