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10.3892/mmr.2015.3391 http://scihub22266oqcxt.onion/10.3892/mmr.2015.3391 C4438945!4438945!25738969     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25738969&cmd=llinks): Failed to open stream: HTTP request failed! 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Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma |pdf=|usr=}}{{25738969}} gab.com Text Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=25738969 #FOAvip Asthma is a serious health problem causing significant mortality and morbidity globally. Persistent airway inflammation, airway hyperresponsiveness, increased immunoglobulin E (IgE) levels and mucus hypersecretion are key characteristics of the condition. Asthma is mediated via a dominant T-helper 2 (Th2) immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma. To investigate the anti-asthmatic potential of afzelin, as well as the underlying mechanisms involved, its anti-asthmatic potential were investigated in a murine model of asthma. In the present study, BALB/c mice were systemically sensitized using ovalbumin (OVA) followed by aerosol allergen challenges. The effect of afzelin on airway hyperresponsiveness, eosinophilic infiltration, Th2 cytokine and OVA-specific IgE production in a mouse model of asthma were investigated. It was found that afzelin-treated groups suppressed eosinophil infiltration, allergic airway inflammation, airway hyperresponsiveness, OVA-specific IgE and Th2 cytokine secretion. The results of the present study suggested that the therapeutic mechanism by which afzelin effectively treats asthma is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production. Twit Text FOAVip Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=25738969 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25738969 #FOAvip English Wikipedia <ref>{{Cite pmid|25738969}}</ref> Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma #MMPMID25738969 ZHOU W; NIE X Mol Med Rep 2015[Jul]; 12 (1): 71-6 PMID25738969show ga Asthma is a serious health problem causing significant mortality and morbidity globally. Persistent airway inflammation, airway hyperresponsiveness, increased immunoglobulin E (IgE) levels and mucus hypersecretion are key characteristics of the condition. Asthma is mediated via a dominant T-helper 2 (Th2) immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma. To investigate the anti-asthmatic potential of afzelin, as well as the underlying mechanisms involved, its anti-asthmatic potential were investigated in a murine model of asthma. In the present study, BALB/c mice were systemically sensitized using ovalbumin (OVA) followed by aerosol allergen challenges. The effect of afzelin on airway hyperresponsiveness, eosinophilic infiltration, Th2 cytokine and OVA-specific IgE production in a mouse model of asthma were investigated. It was found that afzelin-treated groups suppressed eosinophil infiltration, allergic airway inflammation, airway hyperresponsiveness, OVA-specific IgE and Th2 cytokine secretion. The results of the present study suggested that the therapeutic mechanism by which afzelin effectively treats asthma is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production. äAfzelin attenuates asthma phenotypes by downregulation of GATA3 in a m(epmc).pdf DeepDyve Pubget Overpricing