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10.3892/mmr.2015.3348 http://scihub22266oqcxt.onion/10.3892/mmr.2015.3348 C4438917!4438917 !25683840     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25683840 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2015 ; 12 (1 ): 995-1001 Nephropedia Template TP {{tp|p=25683840 |t=2015. Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer |pdf=|usr=}}{{25683840 }} gab.com Text Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=25683840 #FOAvip The objective of the current study was to investigate the impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer (NSCLC). In 115 archived NSCLC tissue samples, the expression of Brachyury was observed to be significantly higher than that in adjacent normal lung tissues. In addition, the current study demonstrated that the expression of Brachyury is closely associated with TNM staging, lymph node metastasis and the prognosis of NSCLC, although not with patient age, gender or tumor differentiation. Brachyury expression is also accompanied by the downregulation of E-cadherin and the upregulation of N-cadherin. Brachyury may promote lung cancer through induction of epithelial-mesenchymal transition, which leads to metastasis and consequent poor prognosis in patients with lung cancer. Furthermore, the present study observed that interfering with Brachyury increases the sensitivity of cells to chemotherapeutic treatment with cisplatin. These results, in combination with those of additional studies, suggest that Brachyury may be used as a novel target for the prevention and treatment of lung cancer. Twit Text FOAVip Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=25683840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25683840 #FOAvip English Wikipedia <ref>{{Cite pmid|25683840 }}</ref> Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer #MMPMID25683840 Xu K ; Liu B ; Liu Y Mol Med Rep 2015[Jul]; 12 (1 ): 995-1001 PMID25683840 show ga The objective of the current study was to investigate the impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer (NSCLC). In 115 archived NSCLC tissue samples, the expression of Brachyury was observed to be significantly higher than that in adjacent normal lung tissues. In addition, the current study demonstrated that the expression of Brachyury is closely associated with TNM staging, lymph node metastasis and the prognosis of NSCLC, although not with patient age, gender or tumor differentiation. Brachyury expression is also accompanied by the downregulation of E-cadherin and the upregulation of N-cadherin. Brachyury may promote lung cancer through induction of epithelial-mesenchymal transition, which leads to metastasis and consequent poor prognosis in patients with lung cancer. Furthermore, the present study observed that interfering with Brachyury increases the sensitivity of cells to chemotherapeutic treatment with cisplatin. These results, in combination with those of additional studies, suggest that Brachyury may be used as a novel target for the prevention and treatment of lung cancer. |*Gene Expression Regulation, Neoplastic [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Antigens, CD/genetics/metabolism [MESH] |Antineoplastic Agents/pharmacology [MESH] |Brachyury Protein [MESH] |Cadherins/genetics/metabolism [MESH] |Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/mortality/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Survival/drug effects [MESH] |Cisplatin/pharmacology [MESH] |Drug Resistance, Neoplasm/drug effects/genetics [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Female [MESH] |Fetal Proteins/antagonists & inhibitors/*genetics/metabolism [MESH] |Humans [MESH] |Lung Neoplasms/*genetics/metabolism/mortality/pathology [MESH] |Lymphatic Metastasis [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasm Staging [MESH] |RNA, Small Interfering/genetics/metabolism [MESH] |Signal Transduction [MESH] |Survival Analysis [MESH]Impact of Brachyury on epithelial-mesenchymal transitions and chemosen(epmc).pdf DeepDyve Pubget Overpricing