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10.1002/eji.201445036 http://scihub22266oqcxt.onion/10.1002/eji.201445036 C4438566!4438566 !25645456     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25645456 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2015 ; 45 (4 ): 988-98 Nephropedia Template TP {{tp|p=25645456 |t=2015. B cells expressing IFN-? suppress Treg-cell differentiation and promote autoimmune experimental arthritis |pdf=|usr=}}{{25645456 }} gab.com Text B cells expressing IFN- suppress Treg-cell differentiation and promote autoimmune experimental arthritis JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25645456 #FOAvip Clinical efficacy in the treatment of rheumatoid arthritis with anti-CD20 (Rituximab)-mediated B-cell depletion has garnered interest in the mechanisms by which B cells contribute to autoimmunity. We have reported that B-cell depletion in a murine model of proteoglycan-induced arthritis (PGIA) leads to an increase in Treg cells that correlate with decreased autoreactivity. Here, we demonstrate that the increase in Treg cells after B-cell depletion is due to an increase in the differentiation of naïve CD4(+) T cells into Treg cells. Since the development of PGIA is dependent on IFN-? and B cells are reported to produce IFN-?, we hypothesized that B-cell-specific IFN-? plays a role in the development of PGIA. Accordingly, mice with B-cell-specific IFN-? deficiency were as resistant to the induction of PGIA as mice that were completely IFN-? deficient. Importantly, despite a normal frequency of IFN-?-producing CD4(+) T cells, B-cell-specific IFN-?-deficient mice exhibited a higher percentage of Treg cells compared with that in WT mice. These data indicate that B-cell IFN-? production inhibits Treg-cell differentiation and exacerbates arthritis. Thus, we have established that IFN-?, specifically derived from B cells, uniquely contributes to the pathogenesis of autoimmunity through prevention of immunoregulatory mechanisms. Twit Text FOAVip B cells expressing IFN- suppress Treg-cell differentiation and promote autoimmune experimental arthritis ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25645456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25645456 #FOAvip English Wikipedia <ref>{{Cite pmid|25645456 }}</ref> B cells expressing IFN-? suppress Treg-cell differentiation and promote autoimmune experimental arthritis #MMPMID25645456 Olalekan SA ; Cao Y ; Hamel KM ; Finnegan A Eur J Immunol 2015[Apr]; 45 (4 ): 988-98 PMID25645456 show ga Clinical efficacy in the treatment of rheumatoid arthritis with anti-CD20 (Rituximab)-mediated B-cell depletion has garnered interest in the mechanisms by which B cells contribute to autoimmunity. We have reported that B-cell depletion in a murine model of proteoglycan-induced arthritis (PGIA) leads to an increase in Treg cells that correlate with decreased autoreactivity. Here, we demonstrate that the increase in Treg cells after B-cell depletion is due to an increase in the differentiation of naïve CD4(+) T cells into Treg cells. Since the development of PGIA is dependent on IFN-? and B cells are reported to produce IFN-?, we hypothesized that B-cell-specific IFN-? plays a role in the development of PGIA. Accordingly, mice with B-cell-specific IFN-? deficiency were as resistant to the induction of PGIA as mice that were completely IFN-? deficient. Importantly, despite a normal frequency of IFN-?-producing CD4(+) T cells, B-cell-specific IFN-?-deficient mice exhibited a higher percentage of Treg cells compared with that in WT mice. These data indicate that B-cell IFN-? production inhibits Treg-cell differentiation and exacerbates arthritis. Thus, we have established that IFN-?, specifically derived from B cells, uniquely contributes to the pathogenesis of autoimmunity through prevention of immunoregulatory mechanisms. |*Lymphocyte Depletion [MESH] |Adjuvants, Immunologic/pharmacology [MESH] |Aggrecans/immunology/pharmacology [MESH] |Animals [MESH] |Antibodies, Monoclonal, Murine-Derived/pharmacology [MESH] |Arthritis, Experimental/*immunology [MESH] |Arthritis, Rheumatoid/immunology [MESH] |B-Lymphocytes/*immunology [MESH] |Cell Differentiation/immunology [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Cytokines/biosynthesis [MESH] |Forkhead Transcription Factors/genetics [MESH] |Interferon-gamma/biosynthesis/genetics/*immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH] |Quaternary Ammonium Compounds/pharmacology [MESH] |Rituximab [MESH]B cells expressing IFN-? suppress Treg-cell differentiation and promot(epmc).pdf DeepDyve Pubget Overpricing