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10.1038/srep10442 http://scihub22266oqcxt.onion/10.1038/srep10442 C4438486!4438486!25990418     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25990418.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=25990418|t=2015. A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer |pdf=|usr=}}{{25990418}} gab.com Text A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25990418 #FOAvip Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), imputing genotypes utilising the 1000 Genomes Project. The combined analysis identified new, significant associations with CRC at 1p36.2 marked by rs72647484 (minor allele frequency [MAF]?=?0.09) near CDC42 and WNT4 (P?=?1.21?×?10?8, odds ratio [OR]?=?1.21 ) and at 16q24.1 marked by rs16941835 (MAF?=?0.21, P?=?5.06?×?10?8; OR?=?1.15) within the long non-coding RNA (lncRNA) RP11-58A18.1 and ~500?kb from the nearest coding gene FOXL1. Additionally we identified a promising association at 10p13 with rs10904849 intronic to CUBN (MAF?=?0.32, P?=?7.01?×?10-8; OR?=?1.14). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CRC. Additionally, our analysis further demonstrates that imputation can be used to exploit GWAS data to identify novel disease-causing variants. Twit Text FOAVip A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25990418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25990418 #FOAvip English Wikipedia <ref>{{Cite pmid|25990418}}</ref> A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer #MMPMID25990418 Al-Tassan NA; Whiffin N; Hosking FJ; Palles C; Farrington SM; Dobbins SE; Harris R; Gorman M; Tenesa A; Meyer BF; Wakil SM; Kinnersley B; Campbell H; Martin L; Smith CG; Idziaszczyk S; Barclay E; Maughan TS; Kaplan R; Kerr R; Kerr D; Buchannan DD; Ko Win A; Hopper J; Jenkins M; Lindor NM; Newcomb PA; Gallinger S; Conti D; Schumacher F; Casey G; Dunlop MG; Tomlinson IP; Cheadle JP; Houlston RS Sci Rep 2015[]; 5 (ä): ä PMID25990418show ga Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), imputing genotypes utilising the 1000 Genomes Project. The combined analysis identified new, significant associations with CRC at 1p36.2 marked by rs72647484 (minor allele frequency [MAF]?=?0.09) near CDC42 and WNT4 (P?=?1.21?×?10?8, odds ratio [OR]?=?1.21 ) and at 16q24.1 marked by rs16941835 (MAF?=?0.21, P?=?5.06?×?10?8; OR?=?1.15) within the long non-coding RNA (lncRNA) RP11-58A18.1 and ~500?kb from the nearest coding gene FOXL1. Additionally we identified a promising association at 10p13 with rs10904849 intronic to CUBN (MAF?=?0.32, P?=?7.01?×?10-8; OR?=?1.14). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CRC. Additionally, our analysis further demonstrates that imputation can be used to exploit GWAS data to identify novel disease-causing variants. äA new GWAS and meta-analysis with 1000Genomes imputation identifies no(epmc).pdf DeepDyve Pubget Overpricing