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10.1093/ckj/sft102

http://scihub22266oqcxt.onion/10.1093/ckj/sft102
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C4438415!4438415!26120443
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suck abstract from ncbi


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pmid26120443      Clin+Kidney+J 2013 ; 6 (5): 500-2
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  • Successful treatment of adult-onset collapsing focal segmental glomerulosclerosis with rituximab #MMPMID26120443
  • Ramachandran R; Rajakumar V; Duseja R; Sakhuja V; Jha V
  • Clin Kidney J 2013[Oct]; 6 (5): 500-2 PMID26120443show ga
  • Collapsing focal segmental glomerulosclerosis (FSGS), or collapsing glomerulopathy (CG), responds poorly to commonly employed therapies, with a high proportion of patients progressing to end-stage renal disease. We report an adult in a nephrotic state, diagnosed with minimal-change disease on biopsy, who failed to respond to steroids, calcineurin inhibitors (CNIs), mycophenolate mofetil and cyclophosphamide. Repeat biopsy showed CG. Treatment with 4 weekly doses of rituximab led to sustained remission of his nephrotic state. This is the first report of adult-onset CG that has responded favourably to rituximab. Rituximab could be a treatment option for patients with this difficult-to-treat condition.
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