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10.1093/ckj/sft100

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C4438413!4438413!26064518
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suck abstract from ncbi


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pmid26064518      Clin+Kidney+J 2013 ; 6 (5): 523-5
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  • Hypouricaemia and hyperuricosuria in familial renal glucosuria #MMPMID26064518
  • Aires I; Santos AR; Pratas J; Nolasco F; Calado J
  • Clin Kidney J 2013[Oct]; 6 (5): 523-5 PMID26064518show ga
  • Familial renal glucosuria is a rare co-dominantly inherited benign phenotype characterized by the presence of glucose in the urine. It is caused by mutations in the SLC5A2 gene that encodes SGLT2, the Na+-glucose cotransporter responsible for the reabsorption of the bulk of glucose in the proximal tubule. We report a case of FRG displaying both severe glucosuria and renal hypouricaemia. We hypothesize that glucosuria can disrupt urate reabsorption in the proximal tubule, directly causing hyperuricosuria.
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