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Eculizumab and drug-induced haemolytic?uraemic syndrome #MMPMID26120441
Faguer S; Huart A; Frémeaux-Bacchi V; Ribes D; Chauveau D
Clin Kidney J 2013[Oct]; 6 (5): 484-5 PMID26120441show ga
The monoclonal anti-C5 antibody eculizumab has been successfully tested in atypical haemolytic-uraemic syndrome (aHUS), with or without mutations in the regulatory proteins of the alternative pathway of the complement, and less convincingly in enterohaemorrhagic Escherichia coli-associated HUS. Here, we report a patient with mitomycin-C-induced HUS unresponsive to plasma exchanges. Eculizumab infusion was followed by a dramatic improvement of haematological parameters and renal function, suggesting a role of complement blockade in the management of refractory, drug-related HUS.