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10.1093/ckj/sft076

http://scihub22266oqcxt.onion/10.1093/ckj/sft076
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C4438392!4438392!26120444
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suck abstract from ncbi


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pmid26120444      Clin+Kidney+J 2013 ; 6 (5): 507-9
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  • Warfarin-related nephropathy in a patient with mild IgA nephropathy on dabigatran and aspirin #MMPMID26120444
  • Moeckel GW; Luciano RL; Brewster UC
  • Clin Kidney J 2013[Oct]; 6 (5): 507-9 PMID26120444show ga
  • Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long-term anticoagulation. We describe a patient who developed acute kidney injury (AKI) in the setting of warfarin conversion to dabigatran, and a renal biopsy demonstrating acute tubular injury. Although the patient had undiagnosed IgA nephropathy that may have predisposed him to bleeding, AKI was due to heme-associated tubular injury. We propose that severe hematuria in patients with underlying glomerular pathology treated with either dabigatran or warfarin may lead to toxic tubular injury through the accumulation of heme-proteins.
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