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2013 ; 6
(6
): 639-42
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gab.com Text
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Recovery of renal function succeeding stem cell transplant: a case of C3
Glomerulonephiritis secondary to monoclonal gammopathy
#MMPMID26069834
Andersen CA
; Marcussen N
; Gregersen JW
Clin Kidney J
2013[Dec]; 6
(6
): 639-42
PMID26069834
show ga
Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN)
can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is
caused by activation of the classical pathway by immune complex formation, and C3
GN results from abnormalities in the alternative pathway of complement. In
previously reported cases of MPGN and C3 GN secondary to monoclonal
gammopathy/multiple myeloma, renal outcome has been poor. Here, we present the
first patient, to our knowledge, who showed full renal recovery and normalization
of the complement system after chemotherapy and stem cell transplantation.