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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Cell+Neurosci 2015 ; 9 (ä): ä Nephropedia Template TP
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An updated role of microRNA-124 in central nervous system disorders: a review #MMPMID26041995
Sun Y; Luo ZM; Guo XM; Su DF; Liu X
Front Cell Neurosci 2015[]; 9 (ä): ä PMID26041995show ga
MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.