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10.1128/MCB.00199-15 http://scihub22266oqcxt.onion/10.1128/MCB.00199-15 C4438237!4438237 !25870108     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25870108 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell+Biol 2015 ; 35 (12 ): 2154-64 Nephropedia Template TP {{tp|p=25870108 |t=2015. Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor ? Signaling and Cardiac Remodeling |pdf=|usr=}}{{25870108 }} gab.com Text Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor Signaling and Cardiac Remodeling JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25870108 #FOAvip The matricellular secreted protein connective tissue growth factor (CTGF) is upregulated in response to cardiac injury or with transforming growth factor ? (TGF-?) stimulation, where it has been suggested to function as a fibrotic effector. Here we generated transgenic mice with inducible heart-specific CTGF overexpression, mice with heart-specific expression of an activated TGF-? mutant protein, mice with heart-specific deletion of Ctgf, and mice in which Ctgf was also deleted from fibroblasts in the heart. Remarkably, neither gain nor loss of CTGF in the heart affected cardiac pathology and propensity toward early lethality due to TGF-? overactivation in the heart. Also, neither heart-specific Ctgf deletion nor CTGF overexpression altered cardiac remodeling and function with aging or after multiple acute stress stimuli. Cardiac fibrosis was also unchanged by modulation of CTGF levels in the heart with aging, pressure overload, agonist infusion, or TGF-? overexpression. However, CTGF mildly altered the overall cardiac response to TGF-? when pressure overload stimulation was applied. CTGF has been proposed to function as a critical TGF-? effector in underlying tissue remodeling and fibrosis throughout the body, although our results suggest that CTGF is of minimal importance and is an unlikely therapeutic vantage point for the heart. Twit Text FOAVip Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor Signaling and Cardiac Remodeling ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25870108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25870108 #FOAvip English Wikipedia <ref>{{Cite pmid|25870108 }}</ref> Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor ? Signaling and Cardiac Remodeling #MMPMID25870108 Accornero F ; van Berlo JH ; Correll RN ; Elrod JW ; Sargent MA ; York A ; Rabinowitz JE ; Leask A ; Molkentin JD Mol Cell Biol 2015[Jun]; 35 (12 ): 2154-64 PMID25870108 show ga The matricellular secreted protein connective tissue growth factor (CTGF) is upregulated in response to cardiac injury or with transforming growth factor ? (TGF-?) stimulation, where it has been suggested to function as a fibrotic effector. Here we generated transgenic mice with inducible heart-specific CTGF overexpression, mice with heart-specific expression of an activated TGF-? mutant protein, mice with heart-specific deletion of Ctgf, and mice in which Ctgf was also deleted from fibroblasts in the heart. Remarkably, neither gain nor loss of CTGF in the heart affected cardiac pathology and propensity toward early lethality due to TGF-? overactivation in the heart. Also, neither heart-specific Ctgf deletion nor CTGF overexpression altered cardiac remodeling and function with aging or after multiple acute stress stimuli. Cardiac fibrosis was also unchanged by modulation of CTGF levels in the heart with aging, pressure overload, agonist infusion, or TGF-? overexpression. However, CTGF mildly altered the overall cardiac response to TGF-? when pressure overload stimulation was applied. CTGF has been proposed to function as a critical TGF-? effector in underlying tissue remodeling and fibrosis throughout the body, although our results suggest that CTGF is of minimal importance and is an unlikely therapeutic vantage point for the heart. |*Signal Transduction [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Connective Tissue Growth Factor/*genetics/*metabolism [MESH] |Fibrosis/genetics/metabolism/pathology [MESH] |Gene Deletion [MESH] |Gene Expression [MESH] |Gene Targeting [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Myocardium/metabolism/*pathology [MESH] |Transforming Growth Factor beta/genetics/*metabolism [MESH]Genetic Analysis of Connective Tissue Growth Factor as an Effector of (epmc).pdf DeepDyve Pubget Overpricing