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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Endocrinol
2015 ; 2015
(ä): 949620
Nephropedia Template TP
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English Wikipedia
Gender-Specific Differences in Clinical Profile and Biochemical Parameters in
Patients with Cushing s Disease: A Single Center Experience
#MMPMID26064114
Liu X
; Zhu X
; Zeng M
; Zhuang Y
; Zhou Y
; Zhang Z
; Yang Y
; Wang Y
; Ye H
; Li Y
Int J Endocrinol
2015[]; 2015
(ä): 949620
PMID26064114
show ga
Cushing's disease (CD) is remarkably prevalent among females; however, more
severe clinical presentation and adverse outcomes have been found in males. The
purpose of this study was to investigate the overall clinical profile and
biochemical parameters in patients with CD to identify the gender differences.
Here we describe our series of CD patients referred to our medical center during
2012-2013. Among 73 cases, females presented a marked preponderance compared to
males. Males had significantly higher ACTH, BMI, HbA1c, systolic blood pressure,
and hemoglobin than females. For the first time, the incidence of fatty liver and
hepatic function was also shown to be elevated in males. Multiple linear
regression analysis was performed to further investigate the correlation of risk
factors with hypokalemia, HbA1c, and systolic blood pressure. Gender and serum
cortisol were associated with hypokalemia. Age, gender, and serum cortisol were
significantly associated with HbA1c. Additionally, only gender was significantly
associated with systolic blood pressure. Regarding clinical presentation, purple
striae seemed to occur more frequently in males than in females. Thus, more
severe clinical presentation, biochemical parameters, and complications were
found in males than in females. Clinical professionals should pay more attention
to the diagnosis and management of males with CD.