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10.1038/srep10205 http://scihub22266oqcxt.onion/10.1038/srep10205 C4437308!4437308!25988972     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=25988972|t=2015. The pluripotency factor NANOG promotes the formation of squamous cell carcinomas |pdf=|usr=}}{{25988972}} gab.com Text The pluripotency factor NANOG promotes the formation of squamous cell carcinomas JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25988972 #FOAvip NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia favours the malignant conversion of skin papillomas induced by chemical carcinogenesis, leading to increased SCC formation. Gene expression analyses in pre-malignant skin indicate that NANOG induces genes associated to epithelial-mesenchymal transition (EMT). Some of these genes are directly activated by NANOG, including EMT-associated genes Zeb1, Zeb2, Twist1, Prrx1 and miR-21. Finally, endogenous NANOG binds to the promoters of theses genes in human SCC cells and, moreover, NANOG induces EMT features in primary keratinocytes. These results provide in vivo evidence for the oncogenic role of NANOG in squamous cell carcinomas. Twit Text FOAVip The pluripotency factor NANOG promotes the formation of squamous cell carcinomas ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25988972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25988972 #FOAvip English Wikipedia <ref>{{Cite pmid|25988972}}</ref> The pluripotency factor NANOG promotes the formation of squamous cell carcinomas #MMPMID25988972 Palla AR; Piazzolla D; Alcazar N; Cañamero M; Graña O; Gómez-López G; Dominguez O; Dueñas M; Paramio JM; Serrano M Sci Rep 2015[]; 5 (ä): ä PMID25988972show ga NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia favours the malignant conversion of skin papillomas induced by chemical carcinogenesis, leading to increased SCC formation. Gene expression analyses in pre-malignant skin indicate that NANOG induces genes associated to epithelial-mesenchymal transition (EMT). Some of these genes are directly activated by NANOG, including EMT-associated genes Zeb1, Zeb2, Twist1, Prrx1 and miR-21. Finally, endogenous NANOG binds to the promoters of theses genes in human SCC cells and, moreover, NANOG induces EMT features in primary keratinocytes. These results provide in vivo evidence for the oncogenic role of NANOG in squamous cell carcinomas. äThe pluripotency factor NANOG promotes the formation of squamous cell (epmc).pdf DeepDyve Pubget Overpricing