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10.1016/j.imbio.2014.07.014 http://scihub22266oqcxt.onion/10.1016/j.imbio.2014.07.014 C4437197!4437197 !25092570     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25092570 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25092570 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunobiology 2014 ; 219 (11 ): 836-44 Nephropedia Template TP {{tp|p=25092570 |t=2014. Late stages of hematopoiesis and B cell lymphopoiesis are regulated by ?-synuclein, a key player in Parkinson s disease |pdf=|usr=}}{{25092570 }} gab.com Text Late stages of hematopoiesis and B cell lymphopoiesis are regulated by -synuclein, a key player in Parkinson s disease JO: Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=25092570 #FOAvip ?-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. ?-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized ?-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell lymphopoiesis. We demonstrated hematologic abnormalities including mild anemia, smaller platelets, lymphopenia but relatively normal early hematopoiesis in KO mice compared to wild-type (WT) as measured in hematopoietic stem cells and progenitors of the different cell lineages. However, the absolute number of B220(+)IgM(+) B cells in bone marrow was reduced by 4-fold in KO mice (WT: 104±23×10(5) vs. KO: 27±5×10(5)). B cells were also reduced in KO spleens associated with effacement of splenic and lymph node architecture. KO mice showed reduced total serum IgG but no abnormality in serum IgM was noted. When KO mice were challenged with a T cell-dependent antigen, production of antigen specific IgG1 and IgG2b was abolished, but antigen specific IgM was not different from WT mice. Our study shows hematologic abnormalities including anemia and smaller platelets, reduced B cell lymphopoiesis and defects in IgG production in the absence of ?-synuclein. This is the first report to show an important role of ?-synuclein late in hematopoiesis, B cell lymphopoiesis and adaptive immune response. Twit Text FOAVip Late stages of hematopoiesis and B cell lymphopoiesis are regulated by -synuclein, a key player in Parkinson s disease ????Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=25092570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25092570 #FOAvip English Wikipedia <ref>{{Cite pmid|25092570 }}</ref> Late stages of hematopoiesis and B cell lymphopoiesis are regulated by ?-synuclein, a key player in Parkinson s disease #MMPMID25092570 Xiao W ; Shameli A ; Harding CV ; Meyerson HJ ; Maitta RW Immunobiology 2014[Nov]; 219 (11 ): 836-44 PMID25092570 show ga ?-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. ?-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized ?-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell lymphopoiesis. We demonstrated hematologic abnormalities including mild anemia, smaller platelets, lymphopenia but relatively normal early hematopoiesis in KO mice compared to wild-type (WT) as measured in hematopoietic stem cells and progenitors of the different cell lineages. However, the absolute number of B220(+)IgM(+) B cells in bone marrow was reduced by 4-fold in KO mice (WT: 104±23×10(5) vs. KO: 27±5×10(5)). B cells were also reduced in KO spleens associated with effacement of splenic and lymph node architecture. KO mice showed reduced total serum IgG but no abnormality in serum IgM was noted. When KO mice were challenged with a T cell-dependent antigen, production of antigen specific IgG1 and IgG2b was abolished, but antigen specific IgM was not different from WT mice. Our study shows hematologic abnormalities including anemia and smaller platelets, reduced B cell lymphopoiesis and defects in IgG production in the absence of ?-synuclein. This is the first report to show an important role of ?-synuclein late in hematopoiesis, B cell lymphopoiesis and adaptive immune response. |Anemia/genetics/immunology [MESH] |Animals [MESH] |Antibody Formation/genetics/immunology [MESH] |Blood Cell Count [MESH] |Blood Platelets/pathology [MESH] |Disease Models, Animal [MESH] |Hematopoiesis/*genetics/immunology [MESH] |Immunity, Humoral/genetics [MESH] |Lymph Nodes/pathology [MESH] |Lymphopenia/genetics/immunology [MESH] |Lymphopoiesis/*genetics/immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Parkinson Disease/*genetics/immunology [MESH] |Phenotype [MESH] |Spleen/pathology [MESH]Late stages of hematopoiesis and B cell lymphopoiesis are regulated by(epmc).pdf DeepDyve Pubget Overpricing