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10.1038/srep09691 http://scihub22266oqcxt.onion/10.1038/srep09691 C4437044!4437044 !25989524     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25989524 &cmd=llinks): Failed to open stream: HTTP request failed! 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In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury |pdf=|usr=}}{{25989524 }} gab.com Text In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25989524 #FOAvip Severe spinal cord injury (SCI) can cause neurological dysfunction and paralysis. However, the early dynamic changes of neurons and their surrounding environment after SCI are poorly understood. Although methylprednisolone (MP) is currently the standard therapeutic agent for treating SCI, its efficacy remains controversial. The purpose of this project was to investigate the early dynamic changes and MP's efficacy on axonal damage, blood flow, and calcium influx into axons in a mouse SCI model. YFP H-line and Thy1-GCaMP transgenic mice were used in this study. Two-photon microscopy was used for imaging of axonal dieback, blood flow, and calcium influx post-injury. We found that MP treatment attenuated progressive damage of axons, increased blood flow, and reduced calcium influx post-injury. Furthermore, microglia/macrophages accumulated in the lesion site after SCI and expressed the proinflammatory mediators iNOS, MCP-1 and IL-1?. MP treatment markedly inhibited the accumulation of microglia/macrophages and reduced the expression of the proinflammatory mediators. MP treatment also improved the recovery of behavioral function post-injury. These findings suggest that MP exerts a neuroprotective effect on SCI treatment by attenuating progressive damage of axons, increasing blood flow, reducing calcium influx, and inhibiting the accumulation of microglia/macrophages after SCI. Twit Text FOAVip In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25989524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25989524 #FOAvip English Wikipedia <ref>{{Cite pmid|25989524 }}</ref> In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury #MMPMID25989524 Tang P ; Zhang Y ; Chen C ; Ji X ; Ju F ; Liu X ; Gan WB ; He Z ; Zhang S ; Li W ; Zhang L Sci Rep 2015[May]; 5 (ä): 9691 PMID25989524 show ga Severe spinal cord injury (SCI) can cause neurological dysfunction and paralysis. However, the early dynamic changes of neurons and their surrounding environment after SCI are poorly understood. Although methylprednisolone (MP) is currently the standard therapeutic agent for treating SCI, its efficacy remains controversial. The purpose of this project was to investigate the early dynamic changes and MP's efficacy on axonal damage, blood flow, and calcium influx into axons in a mouse SCI model. YFP H-line and Thy1-GCaMP transgenic mice were used in this study. Two-photon microscopy was used for imaging of axonal dieback, blood flow, and calcium influx post-injury. We found that MP treatment attenuated progressive damage of axons, increased blood flow, and reduced calcium influx post-injury. Furthermore, microglia/macrophages accumulated in the lesion site after SCI and expressed the proinflammatory mediators iNOS, MCP-1 and IL-1?. MP treatment markedly inhibited the accumulation of microglia/macrophages and reduced the expression of the proinflammatory mediators. MP treatment also improved the recovery of behavioral function post-injury. These findings suggest that MP exerts a neuroprotective effect on SCI treatment by attenuating progressive damage of axons, increasing blood flow, reducing calcium influx, and inhibiting the accumulation of microglia/macrophages after SCI. |*Microscopy, Fluorescence [MESH] |*Photons [MESH] |*Regional Blood Flow [MESH] |Animals [MESH] |Axons/drug effects/*metabolism/pathology [MESH] |Behavior, Animal [MESH] |Calcium/*metabolism [MESH] |Calpain/genetics/metabolism [MESH] |Caspase 3/genetics/metabolism [MESH] |Cell Death/drug effects [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation/drug effects [MESH] |Macrophages/drug effects/metabolism [MESH] |Methylprednisolone/administration & dosage/pharmacology [MESH] |Mice [MESH] |Microcirculation [MESH] |Microglia/drug effects/metabolism [MESH]In vivo two-photon imaging of axonal dieback, blood flow, and calcium (epmc).pdf DeepDyve Pubget Overpricing