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10.1091/mbc.E14-07-1203

http://scihub22266oqcxt.onion/10.1091/mbc.E14-07-1203
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C4436831!4436831!25808491
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suck abstract from ncbi


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pmid25808491      Mol+Biol+Cell 2015 ; 26 (10): 1857-74
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  • Integrin ?3?1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt #MMPMID25808491
  • Yazlovitskaya EM; Tseng HY; Viquez O; Tu T; Mernaugh G; McKee KK; Riggins K; Quaranta V; Pathak A; Carter BD; Yurchenco P; Sonnenberg A; Böttcher RT; Pozzi A; Zent R
  • Mol Biol Cell 2015[May]; 26 (10): 1857-74 PMID25808491show ga
  • This study demonstrates that integrin ?3?1 interactions with both ?3- and ?5-containing laminins regulate ureteric bud (UB) development by functionally modulating the Akt signaling pathway. In addition, the work done shows that K63-linked polyubiquitination plays a previously unrecognized role in integrin ?3?1?dependent cell signaling required for UB development and that this may be a novel general mechanism whereby integrins regulate signaling pathways.
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