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2015 ; 26
(9
): 1764-81
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Sec14-nodulin proteins and the patterning of phosphoinositide landmarks for
developmental control of membrane morphogenesis
#MMPMID25739452
Ghosh R
; de Campos MK
; Huang J
; Huh SK
; Orlowski A
; Yang Y
; Tripathi A
; Nile A
; Lee HC
; Dynowski M
; Schäfer H
; Róg T
; Lete MG
; Ahyayauch H
; Alonso A
; Vattulainen I
; Igumenova TI
; Schaaf G
; Bankaitis VA
Mol Biol Cell
2015[May]; 26
(9
): 1764-81
PMID25739452
show ga
Polarized membrane morphogenesis is a fundamental activity of eukaryotic cells.
This process is essential for the biology of cells and tissues, and its execution
demands exquisite temporal coordination of functionally diverse membrane
signaling reactions with high spatial resolution. Moreover, mechanisms must exist
to establish and preserve such organization in the face of randomizing forces
that would diffuse it. Here we identify the conserved AtSfh1 Sec14-nodulin
protein as a novel effector of phosphoinositide signaling in the extreme
polarized membrane growth program exhibited by growing Arabidopsis root hairs.
The data are consistent with Sec14-nodulin proteins controlling the lateral
organization of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) landmarks
for polarized membrane morphogenesis in plants. This patterning activity requires
both the PtdIns(4,5)P2 binding and homo-oligomerization activities of the AtSfh1
nodulin domain and is an essential aspect of the polarity signaling program in
root hairs. Finally, the data suggest a general principle for how the
phosphoinositide signaling landscape is physically bit mapped so that eukaryotic
cells are able to convert a membrane surface into a high-definition
lipid-signaling screen.
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