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10.1091/mbc.E14-10-1447

http://scihub22266oqcxt.onion/10.1091/mbc.E14-10-1447
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C4436774!4436774!25761634
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suck abstract from ncbi


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pmid25761634      Mol+Biol+Cell 2015 ; 26 (9): 1616-28
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  • ER network formation and membrane fusion by atlastin1/SPG3A disease variants #MMPMID25761634
  • Ulengin I; Park JJ; Lee TH
  • Mol Biol Cell 2015[May]; 26 (9): 1616-28 PMID25761634show ga
  • Atlastin catalyzes GTP-dependent membrane fusion to form the ER network. Mutations in atlastin1 cause the disease hereditary spastic paraplegia (HSP), implying that defects in ER membrane fusion cause HSP. Surprisingly, several disease variants are functional in assays for ER network formation and membrane fusion, warranting rethinking of HSP causation by atlastin1 mutations.
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