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10.1155/2015/428169

http://scihub22266oqcxt.onion/10.1155/2015/428169
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C4436450!4436450!26075239
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suck abstract from ncbi


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pmid26075239      Biomed+Res+Int 2015 ; 2015 (ä): ä
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  • Adverse Events of Monoclonal Antibodies Used for Cancer Therapy #MMPMID26075239
  • Guan M; Zhou YP; Sun JL; Chen SC
  • Biomed Res Int 2015[]; 2015 (ä): ä PMID26075239show ga
  • In 1997, the first monoclonal antibody (MoAb), the chimeric anti-CD20 molecule rituximab, was approved by the US Food and Drug administration for use in cancer patients. Since then, the panel of MoAbs that are approved by international regulatory agencies for the treatment of hematopoietic and solid malignancies has continued to expand, currently encompassing a stunning amount of 20 distinct molecules for 11 targets. We provide a brief scientific background on the use of MoAbs in cancer therapy, review all types of monoclonal antibodies-related adverse events (e.g., allergy, immune-related adverse events, cardiovascular adverse events, and pulmonary adverse events), and discuss the mechanism and treatment of adverse events.
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