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2015 ; 2015
(ä): 807683
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The correlation of serum growth differentiation factor-15 level in patients with
obstructive sleep apnea
#MMPMID26075263
Sari K
; Ede H
; Kapusuz Gencer Z
; Ozkiris M
; Gocmen AY
; Intepe YS
Biomed Res Int
2015[]; 2015
(ä): 807683
PMID26075263
show ga
PURPOSE: Growth differentiation factor-(GDF-) is a prognostic biomarker in
cardiovascular disorders (CVD). GDF-15 level was not studied in patients with
obstructive sleep apnea syndrome (OSAS) before. In this study, we investigated
serum GDF-15 levels in OSAS patients and compared them with healthy controls.
MATERIAL AND METHODS: Polysomnographically, confirmed forty consecutive OSAS
patients (20 men and 20 women) and forty consecutive healthy controls (23 men and
17 women) were enrolled in the study. The samples in each group had similar
demographic characteristics and body mass index (BMI) values. RESULTS: In the
study, no significant correlation was found about GDF-15 levels of OSAS group and
healthy controls. However, there was a significant statistical correlation
between age and GDF-15 level. In correlation analysis, there was not any
significant correlation between age and BMI. CONCLUSION: Although various
developing biomarkers have been studied in cardiovascular disorders, GDF-15
levels have attracted a widespread interest as predictors of cardiovascular risk.
GDF-15 level has not been evaluated previously in patients with OSAS. A
significant statistical correlation was found between age and GDF-15 level. To
reveal close relation between OSAS and GDF-15, further studies are needed with
combination of GDF-15 and other biomarkers in OSAS.