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10.1016/j.tibs.2014.09.003 http://scihub22266oqcxt.onion/10.1016/j.tibs.2014.09.003 C4435807!4435807 !25440716     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25440716 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25440716 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Biochem+Sci 2014 ; 39 (11 ): 556-69 Nephropedia Template TP {{tp|p=25440716 |t=2014. Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback |pdf=|usr=}}{{25440716 }} gab.com Text Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback JO: Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=25440716 #FOAvip In this series of reviews, we are examining ultrasensitive responses, the switch-like input-output relationships that contribute to signal processing in a wide variety of signaling contexts. In the first part of this series, we explored one mechanism for generating ultrasensitivity, zero-order ultrasensitivity, where the saturation of two converting enzymes allows the output to switch from low to high over a tight range of input levels. In this second installment, we focus on three conceptually distinct mechanisms for ultrasensitivity: multisite phosphorylation, stoichiometric inhibitors, and positive feedback. We also examine several related mechanisms and concepts, including cooperativity, reciprocal regulation, coherent feed-forward regulation, and substrate competition, and provide several examples of signaling processes where these mechanisms are known or are suspected to be applicable. Twit Text FOAVip Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback ????Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=25440716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25440716 #FOAvip English Wikipedia <ref>{{Cite pmid|25440716 }}</ref> Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback #MMPMID25440716 Ferrell JE Jr ; Ha SH Trends Biochem Sci 2014[Nov]; 39 (11 ): 556-69 PMID25440716 show ga In this series of reviews, we are examining ultrasensitive responses, the switch-like input-output relationships that contribute to signal processing in a wide variety of signaling contexts. In the first part of this series, we explored one mechanism for generating ultrasensitivity, zero-order ultrasensitivity, where the saturation of two converting enzymes allows the output to switch from low to high over a tight range of input levels. In this second installment, we focus on three conceptually distinct mechanisms for ultrasensitivity: multisite phosphorylation, stoichiometric inhibitors, and positive feedback. We also examine several related mechanisms and concepts, including cooperativity, reciprocal regulation, coherent feed-forward regulation, and substrate competition, and provide several examples of signaling processes where these mechanisms are known or are suspected to be applicable. |*Feedback, Physiological [MESH] |Animals [MESH] |Binding Sites [MESH] |Binding, Competitive [MESH] |Enzyme Inhibitors/*metabolism/pharmacology [MESH] |Humans [MESH] |Kinetics [MESH] |Phosphoprotein Phosphatases/antagonists & inhibitors/*metabolism [MESH] |Phosphorylation/drug effects [MESH]Ultrasensitivity part II: multisite phosphorylation, stoichiometric in(epmc).pdf DeepDyve Pubget Overpricing