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10.7326/M14-1336 http://scihub22266oqcxt.onion/10.7326/M14-1336 C4435698!4435698 !25775312     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25775312 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Intern+Med 2015 ; 162 (6 ): 397-406 Nephropedia Template TP {{tp|p=25775312 |t=2015. Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States |pdf=|usr=}}{{25775312 }} gab.com Text Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States JO: Ann Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=25775312 #FOAvip BACKGROUND: Sofosbuvir and ledipasvir, which have recently been approved for treatment of chronic hepatitis C virus (HCV) infection, are more efficacious and safer than the old standard of care (oSOC) but are substantially more expensive. Whether and in which patients their improved efficacy justifies their increased cost is unclear. OBJECTIVE: To evaluate the cost-effectiveness and budget impact of sofosbuvir and ledipasvir. DESIGN: Microsimulation model of the natural history of HCV infection. DATA SOURCES: Published literature. TARGET POPULATION: Treatment-naive and treatment-experienced HCV population defined on the basis of HCV genotype, age, and fibrosis distribution in the United States. TIME HORIZON: Lifetime. PERSPECTIVE: Third-party payer. INTERVENTION: Simulation of sofosbuvir-ledipasvir compared with the oSOC (interferon-based therapies). OUTCOME MEASURES: Quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios (ICERs), and 5-year spending on antiviral drugs. RESULTS OF BASE-CASE ANALYSIS: Sofosbuvir-based therapies added 0.56 QALY relative to the oSOC at an ICER of $55 400 per additional QALY. The ICERs ranged from $9700 to $284 300 per QALY depending on the patient's status with respect to treatment history, HCV genotype, and presence of cirrhosis. At a willingness-to-pay threshold of $100 000 per QALY, sofosbuvir-based therapies were cost-effective in 83% of treatment-naive and 81% of treatment-experienced patients. Compared with the oSOC, treating eligible HCV-infected persons in the United States with the new drugs would cost an additional $65 billion in the next 5 years, whereas the resulting cost offsets would be $16 billion. RESULTS OF SENSITIVITY ANALYSIS: Results were sensitive to drug price, drug efficacy, and quality of life after successful treatment. LIMITATION: Data on real-world effectiveness of new antivirals are lacking. CONCLUSION: Treatment of HCV is cost-effective in most patients, but additional resources and value-based patient prioritization are needed to manage patients with HCV. PRIMARY FUNDING SOURCE: National Institutes of Health. Twit Text FOAVip Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States ????Ann Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=25775312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25775312 #FOAvip English Wikipedia <ref>{{Cite pmid|25775312 }}</ref> Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States #MMPMID25775312 Chhatwal J ; Kanwal F ; Roberts MS ; Dunn MA Ann Intern Med 2015[Mar]; 162 (6 ): 397-406 PMID25775312 show ga BACKGROUND: Sofosbuvir and ledipasvir, which have recently been approved for treatment of chronic hepatitis C virus (HCV) infection, are more efficacious and safer than the old standard of care (oSOC) but are substantially more expensive. Whether and in which patients their improved efficacy justifies their increased cost is unclear. OBJECTIVE: To evaluate the cost-effectiveness and budget impact of sofosbuvir and ledipasvir. DESIGN: Microsimulation model of the natural history of HCV infection. DATA SOURCES: Published literature. TARGET POPULATION: Treatment-naive and treatment-experienced HCV population defined on the basis of HCV genotype, age, and fibrosis distribution in the United States. TIME HORIZON: Lifetime. PERSPECTIVE: Third-party payer. INTERVENTION: Simulation of sofosbuvir-ledipasvir compared with the oSOC (interferon-based therapies). OUTCOME MEASURES: Quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios (ICERs), and 5-year spending on antiviral drugs. RESULTS OF BASE-CASE ANALYSIS: Sofosbuvir-based therapies added 0.56 QALY relative to the oSOC at an ICER of $55 400 per additional QALY. The ICERs ranged from $9700 to $284 300 per QALY depending on the patient's status with respect to treatment history, HCV genotype, and presence of cirrhosis. At a willingness-to-pay threshold of $100 000 per QALY, sofosbuvir-based therapies were cost-effective in 83% of treatment-naive and 81% of treatment-experienced patients. Compared with the oSOC, treating eligible HCV-infected persons in the United States with the new drugs would cost an additional $65 billion in the next 5 years, whereas the resulting cost offsets would be $16 billion. RESULTS OF SENSITIVITY ANALYSIS: Results were sensitive to drug price, drug efficacy, and quality of life after successful treatment. LIMITATION: Data on real-world effectiveness of new antivirals are lacking. CONCLUSION: Treatment of HCV is cost-effective in most patients, but additional resources and value-based patient prioritization are needed to manage patients with HCV. PRIMARY FUNDING SOURCE: National Institutes of Health. |*Drug Costs [MESH] |Antiviral Agents/*economics/*therapeutic use [MESH] |Benzimidazoles/*economics/*therapeutic use [MESH] |Budgets [MESH] |Cost-Benefit Analysis [MESH] |Fluorenes/*economics/*therapeutic use [MESH] |Genotype [MESH] |Hepacivirus/genetics [MESH] |Hepatitis C, Chronic/*drug therapy [MESH] |Humans [MESH] |Insurance, Health, Reimbursement/economics [MESH] |Interferon-alpha/economics/therapeutic use [MESH] |Markov Chains [MESH] |Patient-Specific Modeling [MESH] |Quality-Adjusted Life Years [MESH] |Sofosbuvir [MESH] |United States [MESH]Cost-effectiveness and budget impact of hepatitis C virus treatment wi(epmc).pdf DeepDyve Pubget Overpricing