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10.1038/mt.2014.91 http://scihub22266oqcxt.onion/10.1038/mt.2014.91 C4435497!4435497 !24861055     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24861055 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Ther 2014 ; 22 (9 ): 1698-706 Nephropedia Template TP {{tp|p=24861055 |t=2014. Epigenetic manipulation restores functions of defective CD8? T cells from chronic viral infection |pdf=|usr=}}{{24861055 }} gab.com Text Epigenetic manipulation restores functions of defective CD8 T cells from chronic viral infection JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24861055 #FOAvip Functional exhaustion of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T cell dysfunction are not well understood. Epigenetics plays an important role in the control of T cell development, differentiation, and function. To examine if epigenetics also plays a role in T cell exhaustion, we analyzed chromatin remodeling in CD8(+) T cells from mice with chronic lymphocytic choriomeningitis virus infection. We observed downregulation of diacetylated histone H3 in both virus-specific and total CD8(+) T cells, and functional defects not only in virus-specific CD8(+) T cells but also within the total CD8(+) T cell population. In vitro treatment of these exhausted CD8(+) T cells with histone deacetylase inhibitors restored diacetylated histone H3 levels, and improved their immune functions. Upon adoptive transfer, these treated CD8(+) T cells developed into functional memory T cells in vivo that enhanced protective immunity. These results define a role of epigenetics in T cell exhaustion and suggest epigenetic manipulation as a novel molecular therapy to restore immune functions. Twit Text FOAVip Epigenetic manipulation restores functions of defective CD8 T cells from chronic viral infection ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24861055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24861055 #FOAvip English Wikipedia <ref>{{Cite pmid|24861055 }}</ref> Epigenetic manipulation restores functions of defective CD8? T cells from chronic viral infection #MMPMID24861055 Zhang F ; Zhou X ; DiSpirito JR ; Wang C ; Wang Y ; Shen H Mol Ther 2014[Sep]; 22 (9 ): 1698-706 PMID24861055 show ga Functional exhaustion of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T cell dysfunction are not well understood. Epigenetics plays an important role in the control of T cell development, differentiation, and function. To examine if epigenetics also plays a role in T cell exhaustion, we analyzed chromatin remodeling in CD8(+) T cells from mice with chronic lymphocytic choriomeningitis virus infection. We observed downregulation of diacetylated histone H3 in both virus-specific and total CD8(+) T cells, and functional defects not only in virus-specific CD8(+) T cells but also within the total CD8(+) T cell population. In vitro treatment of these exhausted CD8(+) T cells with histone deacetylase inhibitors restored diacetylated histone H3 levels, and improved their immune functions. Upon adoptive transfer, these treated CD8(+) T cells developed into functional memory T cells in vivo that enhanced protective immunity. These results define a role of epigenetics in T cell exhaustion and suggest epigenetic manipulation as a novel molecular therapy to restore immune functions. |*Epigenesis, Genetic [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |Arenaviridae Infections/*immunology/virology [MESH] |CD8-Positive T-Lymphocytes/*metabolism/virology [MESH] |Chromatin Assembly and Disassembly [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Female [MESH] |Histones/metabolism [MESH] |Lymphocytic Choriomeningitis/immunology/*veterinary/virology [MESH] |Lymphocytic choriomeningitis virus/*physiology [MESH] |Mice [MESH]Epigenetic manipulation restores functions of defective CD8? 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