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10.3389/fnins.2015.00173 http://scihub22266oqcxt.onion/10.3389/fnins.2015.00173 C4434977!4434977!26041981     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Neurosci 2015 ; 9 (ä): ä Nephropedia Template TP {{tp|p=26041981|t=2015. Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration |pdf=|usr=}}{{26041981}} gab.com Text Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration JO: Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26041981 #FOAvip Alzheimer's disease (AD) is a complex, multifactorial disease with a number of leading mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to amyloid ? peptide, tau protein hyperphosphorylation, relocalization, and deposition. These mechanisms are propagated by obesity, the metabolic syndrome and type-2 diabetes mellitus. Stress, sedentariness, dietary overconsumption of saturated fat and refined sugars, and circadian derangements/disturbed sleep contribute to obesity and related metabolic diseases, but also accelerate age-related damage and senescence that all feed the risk of developing AD too. The complex and interacting mechanisms are not yet completely understood and will require further analysis. Instead of investigating AD as a mono- or oligocausal disease we should address the disease by understanding the multiple underlying mechanisms and how these interact. Future research therefore might concentrate on integrating these by ?systems biology? approaches, but also to regard them from an evolutionary medicine point of view. The current review addresses several of these interacting mechanisms in animal models and compares them with clinical data giving an overview about our current knowledge and puts them into an integrated framework. Twit Text FOAVip Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration ????Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26041981 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26041981 #FOAvip English Wikipedia <ref>{{Cite pmid|26041981}}</ref> Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration #MMPMID26041981 van Dijk G; van Heijningen S; Reijne AC; Nyakas C; van der Zee EA; Eisel ULM Front Neurosci 2015[]; 9 (ä): ä PMID26041981show ga Alzheimer's disease (AD) is a complex, multifactorial disease with a number of leading mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to amyloid ? peptide, tau protein hyperphosphorylation, relocalization, and deposition. These mechanisms are propagated by obesity, the metabolic syndrome and type-2 diabetes mellitus. Stress, sedentariness, dietary overconsumption of saturated fat and refined sugars, and circadian derangements/disturbed sleep contribute to obesity and related metabolic diseases, but also accelerate age-related damage and senescence that all feed the risk of developing AD too. The complex and interacting mechanisms are not yet completely understood and will require further analysis. Instead of investigating AD as a mono- or oligocausal disease we should address the disease by understanding the multiple underlying mechanisms and how these interact. Future research therefore might concentrate on integrating these by ?systems biology? approaches, but also to regard them from an evolutionary medicine point of view. The current review addresses several of these interacting mechanisms in animal models and compares them with clinical data giving an overview about our current knowledge and puts them into an integrated framework. äIntegrative neurobiology of metabolic diseases, neuroinflammation, and(epmc).pdf DeepDyve Pubget Overpricing