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10.1242/bio.201511478 http://scihub22266oqcxt.onion/10.1242/bio.201511478 C4434813!4434813!25862247     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25862247&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Open 2015 ; 4 (5): 622-6 Nephropedia Template TP {{tp|p=25862247|t=2015. Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function |pdf=|usr=}}{{25862247}} gab.com Text Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function JO: Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=25862247 #FOAvip Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by decreasing myocellular damage and enhancing functional recovery. Our in vitro and in vivo studies established that autologous mitochondria are internalized into cardiomyocytes following transplantation; however, the mechanism(s) modulating internalization of these organelles were unknown. Here, we show that internalization of mitochondria occurs through actin-dependent endocytosis and rescues cell function by increasing ATP content and oxygen consumption rates. We also show that internalized mitochondria replace depleted mitochondrial (mt)DNA. These results describe the mechanism for internalization of mitochondria within host cells and provide a basis for novel therapeutic interventions allowing for the rescue and replacement of damaged or impaired mitochondria. Twit Text FOAVip Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function ????Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=25862247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25862247 #FOAvip English Wikipedia <ref>{{Cite pmid|25862247}}</ref> Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function #MMPMID25862247 Pacak CA; Preble JM; Kondo H; Seibel P; Levitsky S; del Nido PJ; Cowan DB; McCully JD Biol Open 2015[May]; 4 (5): 622-6 PMID25862247show ga Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by decreasing myocellular damage and enhancing functional recovery. Our in vitro and in vivo studies established that autologous mitochondria are internalized into cardiomyocytes following transplantation; however, the mechanism(s) modulating internalization of these organelles were unknown. Here, we show that internalization of mitochondria occurs through actin-dependent endocytosis and rescues cell function by increasing ATP content and oxygen consumption rates. We also show that internalized mitochondria replace depleted mitochondrial (mt)DNA. These results describe the mechanism for internalization of mitochondria within host cells and provide a basis for novel therapeutic interventions allowing for the rescue and replacement of damaged or impaired mitochondria. äActin-dependent mitochondrial internalization in cardiomyocytes: evide(epmc).pdf DeepDyve Pubget Overpricing