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10.1038/ncb3160 http://scihub22266oqcxt.onion/10.1038/ncb3160 C4434585!4434585!25915126     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2015 ; 17 (5): 615-26 Nephropedia Template TP {{tp|p=25915126|t=2015. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors |pdf=|usr=}}{{25915126}} gab.com Text TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25915126 #FOAvip The genomic regulatory programs that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer, and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic stem cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signaling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signaling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role of TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas. Twit Text FOAVip TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25915126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25915126 #FOAvip English Wikipedia <ref>{{Cite pmid|25915126}}</ref> TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors #MMPMID25915126 Cebola I; Rodríguez-Seguí SA; Cho CHH; Bessa J; Rovira M; Luengo M; Chhatriwala M; Berry A; Ponsa-Cobas J; Maestro MA; Jennings RE; Pasquali L; Morán I; Castro N; Hanley NA; Gomez-Skarmeta JL; Vallier L; Ferrer J Nat Cell Biol 2015[May]; 17 (5): 615-26 PMID25915126show ga The genomic regulatory programs that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer, and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic stem cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signaling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signaling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role of TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas. äTEAD and YAP regulate the enhancer network of human embryonic pancreat(epmc).pdf DeepDyve Pubget Overpricing