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10.5665/sleep.4726

http://scihub22266oqcxt.onion/10.5665/sleep.4726
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C4434551!4434551!26163465
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suck abstract from ncbi


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pmid26163465      Sleep ä ; 38 (6): 853-8
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  • Virchow-Robin Spaces: Correlations with Polysomnography-Derived Sleep Parameters #MMPMID26163465
  • Berezuk C; Ramirez J; Gao F; Scott CJ; Huroy M; Swartz RH; Murray BJ; Black SE; Boulos MI
  • Sleep ä[]; 38 (6): 853-8 PMID26163465show ga
  • Study Objectives:: To test the hypothesis that enlarged Virchow-Robin space volumes (VRS) are associated with objective measures of poor quality sleep. Design:: Retrospective cross-sectional study. Setting:: Sunnybrook Health Sciences Centre. Patients:: Twenty-six patients being evaluated for cerebrovascular disease were assessed using polysomnography and high-resolution structural magnetic resonance imaging. Measurements and Results:: Regionalized VRS were quantified from three-dimensional high-resolution magnetic resonance imaging and correlated with measures of polysomnography-derived sleep parameters while controlling for age, stroke volume, body mass index, systolic blood pressure, and ventricular cerebrospinal fluid volume. Sleep efficiency was negatively correlated with total VRS (rho = ?0.47, P = 0.03) and basal ganglia VRS (rho = ?0.54, P = 0.01), whereas wake after sleep onset was positively correlated with basal ganglia VRS (rho = 0.52, P = 0.02). Furthermore, VRS in the basal ganglia were negatively correlated with duration of N3 (rho = ?0.53, P = 0.01). Conclusions:: These preliminary results suggest that sleep may play a role in perivascular clearance in ischemic brain disease, and invite future research into the potential relevance of Virchow-Robin spaces as an imaging biomarker for nocturnal metabolite clearance. Citation:: Berezuk C, Ramirez J, Gao F, Scott CJ, Huroy M, Swartz RH, Murray BJ, Black SE, Boulos MI. Virchow-Robin spaces: correlations with polysomnography-derived sleep parameters. SLEEP 2015;38(6):853?858.
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