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10.4049/jimmunol.1403181 http://scihub22266oqcxt.onion/10.4049/jimmunol.1403181 C4433809!4433809!25888642     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25888642&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (11): 5120-8 Nephropedia Template TP {{tp|p=25888642|t=2015. Interferon ? selectively Inhibits Interleukin-2 (IL-2) production through cAMP responsive element modulator (CREM)-mediated chromatin remodeling |pdf=|usr=}}{{25888642}} gab.com Text Interferon selectively Inhibits Interleukin-2 (IL-2) production through cAMP responsive element modulator (CREM)-mediated chromatin remodeling JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25888642 #FOAvip Interferon beta (IFN?) is widely used in the treatment of multiple sclerosis, yet the mechanism facilitating its efficacy remains unclear. IL-2 production by activated T cells, including those mediating autoimmunity, and subsequent autocrine stimulation is vital for T cell expansion and function. Here we demonstrate that in both mouse and human T cells, IFN? specifically inhibits the production of IL-2 upon T cell receptor (TCR) engagement without affecting other cytokines or activation markers. Rather than disrupting TCR signaling, IFN? alters histone modifications in the IL-2 promoter to retain the locus in an inaccessible configuration. This in turn is mediated through the upregulation of the transcriptional suppressor CREM by IFN? and consequent recruitment of histone deacetylases (HDACs) to the IL-2 promoter. In accordance, ablation of CREM expression or inhibition of HDAC activity eliminates the suppressive effects of IFN? on IL-2 production. Collectively, these findings provide a molecular basis by which IFN? limits T cell responses. Twit Text FOAVip Interferon selectively Inhibits Interleukin-2 (IL-2) production through cAMP responsive element modulator (CREM)-mediated chromatin remodeling ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25888642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25888642 #FOAvip English Wikipedia <ref>{{Cite pmid|25888642}}</ref> Interferon ? selectively Inhibits Interleukin-2 (IL-2) production through cAMP responsive element modulator (CREM)-mediated chromatin remodeling #MMPMID25888642 Otero DC; Fares-Frederickson NJ; Xiao M; Baker DP; David M J Immunol 2015[Jun]; 194 (11): 5120-8 PMID25888642show ga Interferon beta (IFN?) is widely used in the treatment of multiple sclerosis, yet the mechanism facilitating its efficacy remains unclear. IL-2 production by activated T cells, including those mediating autoimmunity, and subsequent autocrine stimulation is vital for T cell expansion and function. Here we demonstrate that in both mouse and human T cells, IFN? specifically inhibits the production of IL-2 upon T cell receptor (TCR) engagement without affecting other cytokines or activation markers. Rather than disrupting TCR signaling, IFN? alters histone modifications in the IL-2 promoter to retain the locus in an inaccessible configuration. This in turn is mediated through the upregulation of the transcriptional suppressor CREM by IFN? and consequent recruitment of histone deacetylases (HDACs) to the IL-2 promoter. In accordance, ablation of CREM expression or inhibition of HDAC activity eliminates the suppressive effects of IFN? on IL-2 production. Collectively, these findings provide a molecular basis by which IFN? limits T cell responses. äInterferon ? selectively Inhibits Interleukin-2 (IL-2) production thro(epmc).pdf DeepDyve Pubget Overpricing