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10.1155/2015/851945 http://scihub22266oqcxt.onion/10.1155/2015/851945 C4433691!4433691!26065007     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol+Res 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26065007|t=2015. Innate and Adaptive Immunity in Calcific Aortic Valve Disease |pdf=|usr=}}{{26065007}} gab.com Text Innate and Adaptive Immunity in Calcific Aortic Valve Disease JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26065007 #FOAvip Calcific aortic valve disease (CAVD) is the most common heart valve disorder. CAVD is a chronic process characterized by a pathologic mineralization of valve leaflets. Ectopic mineralization of the aortic valve involves complex relationships with immunity. Studies have highlighted that both innate and adaptive immunity play a role in the development of CAVD. In this regard, accumulating evidence indicates that fibrocalcific remodelling of the aortic valve is associated with activation of the NF-?B pathway. The expression of TNF-? and IL-6 is increased in human mineralized aortic valves and promotes an osteogenic program as well as the mineralization of valve interstitial cells (VICs), the main cellular component of the aortic valve. Different factors, including oxidized lipid species, activate the innate immune response through the Toll-like receptors. Moreover, VICs express 5-lipoxygenase and therefore produce leukotrienes, which may amplify the inflammatory response in the aortic valve. More recently, studies have emphasized that an adaptive immune response is triggered during CAVD. Herein, we are reviewing the link between the immune response and the development of CAVD and we have tried, whenever possible, to keep a translational approach. Twit Text FOAVip Innate and Adaptive Immunity in Calcific Aortic Valve Disease ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26065007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26065007 #FOAvip English Wikipedia <ref>{{Cite pmid|26065007}}</ref> Innate and Adaptive Immunity in Calcific Aortic Valve Disease #MMPMID26065007 Mathieu P; Bouchareb R; Boulanger MC J Immunol Res 2015[]; 2015 (ä): ä PMID26065007show ga Calcific aortic valve disease (CAVD) is the most common heart valve disorder. CAVD is a chronic process characterized by a pathologic mineralization of valve leaflets. Ectopic mineralization of the aortic valve involves complex relationships with immunity. Studies have highlighted that both innate and adaptive immunity play a role in the development of CAVD. In this regard, accumulating evidence indicates that fibrocalcific remodelling of the aortic valve is associated with activation of the NF-?B pathway. The expression of TNF-? and IL-6 is increased in human mineralized aortic valves and promotes an osteogenic program as well as the mineralization of valve interstitial cells (VICs), the main cellular component of the aortic valve. Different factors, including oxidized lipid species, activate the innate immune response through the Toll-like receptors. Moreover, VICs express 5-lipoxygenase and therefore produce leukotrienes, which may amplify the inflammatory response in the aortic valve. More recently, studies have emphasized that an adaptive immune response is triggered during CAVD. Herein, we are reviewing the link between the immune response and the development of CAVD and we have tried, whenever possible, to keep a translational approach. äInnate and Adaptive Immunity in Calcific Aortic Valve Disease (epmc).pdf DeepDyve Pubget Overpricing