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10.1155/2015/639587

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suck abstract from ncbi


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pmid26064934
      Biomed+Res+Int 2015 ; 2015 (ä): 639587
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  • Parathyroidectomy Is Associated with Reduced Mortality in Hemodialysis Patients with Secondary Hyperparathyroidism #MMPMID26064934
  • Ma TL ; Hung PH ; Jong IC ; Hiao CY ; Hsu YH ; Chiang PC ; Guo HR ; Hung KY
  • Biomed Res Int 2015[]; 2015 (ä): 639587 PMID26064934 show ga
  • Secondary hyperparathyroidism increases morbidity and mortality in hemodialysis patients. The Kidney Disease Outcomes Quality Initiative Guidelines recommend parathyroidectomy for patients with chronic kidney disease and parathyroid hormone concentrations exceeding 800?pg/mL; however, this concentration represents an arbitrary cut-off value. The present study was conducted to identify factors influencing mortality in hemodialysis patients with parathyroid hormone concentrations exceeding 800?pg/mL and to evaluate the effects of parathyroidectomy on outcome for these patients. Two hundred twenty-one hemodialysis patients with parathyroid hormone concentrations > 800?pg/mL from July 2004 to June 2010 were identified. 21.1% of patients (n = 60) received parathyroidectomy and 14.9% of patients (n = 33) died during a mean follow-up of 36 months. Patients with parathyroidectomy were found to have lower all-cause mortality (adjusted hazard ratio [aHR]: 0.34). Other independent predictors included age ? 65 years (aHR: 2.11) and diabetes mellitus (aHR: 3.80). For cardiovascular mortality, parathyroidectomy was associated with lower mortality (HR = 0.31) but with a marginal statistical significance (p = 0.061). In multivariate analysis, diabetes was the only significant predictor (aHR: 3.14). It is concluded that, for hemodialysis patients with parathyroid hormone concentrations greater than 800?pg/mL, parathyroidectomy is associated with reduced all-cause mortality.
  • |*Parathyroidectomy [MESH]
  • |Aged [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hyperparathyroidism, Secondary/blood/mortality/pathology/*surgery [MESH]
  • |Kidney Failure, Chronic/blood/mortality/pathology/*surgery [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Parathyroid Hormone/blood [MESH]
  • |Renal Dialysis/mortality [MESH]


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