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Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with
Properties of Progressive Human CKD
#MMPMID26064882
Mohammed-Ali Z
; Cruz GL
; Lu C
; Carlisle RE
; Werner KE
; Ask K
; Dickhout JG
Biomed Res Int
2015[]; 2015
(?): 172302
PMID26064882
show ga
Chronic kidney disease (CKD) is a major healthcare problem with increasing
prevalence in the population. CKD leads to end stage renal disease and increases
the risk of cardiovascular disease. As such, it is important to study the
mechanisms underlying CKD progression. To this end, an animal model was developed
to allow the testing of new treatment strategies or molecular targets for CKD
prevention. Many underlying risk factors result in CKD but the disease itself has
common features, including renal interstitial fibrosis, tubular epithelial cell
loss through apoptosis, glomerular damage, and renal inflammation. Further, CKD
shows differences in prevalence between the genders with premenopausal women
being relatively resistant to CKD. We sought to develop and characterize an
animal model with these common features of human CKD in the C57BL/6 mouse. Mice
of this genetic background have been used to produce transgenic strains that are
commercially available. Thus, a CKD model in this strain would allow the testing
of the effects of numerous genes on the severity or progression of CKD with
minimal cost. This paper describes such a mouse model of CKD utilizing
angiotensin II and deoxycorticosterone acetate as inducers.
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