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10.1158/0008-5472.CAN-14-2761 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2761 C4433621!4433621!25769722     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25769722&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2015 ; 75 (10): 1972-82 Nephropedia Template TP {{tp|p=25769722|t=2015. Paracrine WNT5A signaling inhibits expansion of tumor-initiating cells |pdf=|usr=}}{{25769722}} gab.com Text Paracrine WNT5A signaling inhibits expansion of tumor-initiating cells JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25769722 #FOAvip It is not well understood how paracrine communication between basal and luminal cell populations in the mammary gland affects tumorigenesis. During ErbB2-induced mammary tumorigenesis, enriched mammary stem cells that represent a subpopulation of basal cells exhibit enhanced tumorigenic capacity compared to the corresponding luminal progenitors. Transcript profiling of tumors derived from basal and luminal tumor-initiating cells (TIC) revealed preferential loss of the noncanonical Wnt ligand WNT5A in basal TIC-derived tumors. Heterozygous loss of WNT5A was correlated with shorter survival of breast cancer patients. In a mouse model of ErbB2-induced breast cancer, Wnt5a heterozygosity promoted tumor multiplicity and pulmonary metastasis. As a TGF? substrate, luminal cell-produced WNT5A induced a feed-forward loop to activate SMAD2 in a RYK and TGF?R1-dependent manner to limit the expansion of basal TIC in a paracrine fashion, a potential explanation for the suppressive effect of WNT5A in mammary tumorigenesis. Our results identify the WNT5A/RYK module as a spatial regulator of TGF?/SMAD signaling pathway in the context of mammary gland development and carcinogenesis, offering a new perspective on tumor suppression provided by basal-luminal crosstalk in normal mammary tissue. Twit Text FOAVip Paracrine WNT5A signaling inhibits expansion of tumor-initiating cells ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25769722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25769722 #FOAvip English Wikipedia <ref>{{Cite pmid|25769722}}</ref> Paracrine WNT5A signaling inhibits expansion of tumor-initiating cells #MMPMID25769722 Borcherding N; Kusner D; Kolb R; Xie Q; Li W; Yuan F; Velez G; Askeland R; Weigel RJ; Zhang W Cancer Res 2015[May]; 75 (10): 1972-82 PMID25769722show ga It is not well understood how paracrine communication between basal and luminal cell populations in the mammary gland affects tumorigenesis. During ErbB2-induced mammary tumorigenesis, enriched mammary stem cells that represent a subpopulation of basal cells exhibit enhanced tumorigenic capacity compared to the corresponding luminal progenitors. Transcript profiling of tumors derived from basal and luminal tumor-initiating cells (TIC) revealed preferential loss of the noncanonical Wnt ligand WNT5A in basal TIC-derived tumors. Heterozygous loss of WNT5A was correlated with shorter survival of breast cancer patients. In a mouse model of ErbB2-induced breast cancer, Wnt5a heterozygosity promoted tumor multiplicity and pulmonary metastasis. As a TGF? substrate, luminal cell-produced WNT5A induced a feed-forward loop to activate SMAD2 in a RYK and TGF?R1-dependent manner to limit the expansion of basal TIC in a paracrine fashion, a potential explanation for the suppressive effect of WNT5A in mammary tumorigenesis. Our results identify the WNT5A/RYK module as a spatial regulator of TGF?/SMAD signaling pathway in the context of mammary gland development and carcinogenesis, offering a new perspective on tumor suppression provided by basal-luminal crosstalk in normal mammary tissue. äParacrine WNT5A signaling inhibits expansion of tumor-initiating cells(epmc).pdf DeepDyve Pubget Overpricing